ABSTRACT
The Authors report their experience on the vulvar carcinoma therapy. Patients showed, with high frequency, hypertension and diabetes. The 25.9% of the patients, furthermore, were obese. The surgery was the primary treatment, combined with chemiotherapy and radiotherapy in selected cases. The survival rate was 80% in I stage, while in the III and IV stage was very low, in spite of the use of chemotherapy.
Subject(s)
Adenocarcinoma/therapy , Carcinoma, Squamous Cell/therapy , Vulvar Neoplasms/therapy , Aged , Aged, 80 and over , Combined Modality Therapy , Female , Humans , Middle Aged , PrognosisABSTRACT
Penicillin-resistant mutants were isolated for six strains of Streptococcus cremoris used in commercial Cheddar cheese manufacture after treatment with N-methyl-N-nitro-N-nitrosoguanidine. The resistant mutants had an elevated minimal growth inhibitory concentration, 2.5 micrograms (4.13 units)/ml, for penicillin G and other beta-lactam antibiotics as compared with the penicillin-susceptible parent strains, which were each sensitive to .05 micrograms (.08 units)/ml. Penicillin resistance was due to the production of beta-lactamase. Plasmid DNA was not demonstrated in partially purified lysates of four mutants. Mutants had normal cellular morphology but altered phage sensitivity patterns. All except one strain were able to support complete phage adsorption. Resistance was retained after 20 passages in absence of penicillin.
