[In vitro study of macrophage barrier function in mice vaccinated against tick-borne encephalitis and infection with flaviviruses of varying virulence]. / Issledovanie in vitro bar'ernoi funktsii makrofagov myshei pri vaktsinatsii protiv kleshchevogo éntsefalita i infektsii flavivirusami s razlichnoi virulentnost'iu.

Tick-borne encephalitis (TBE) and Langat viruses were shown to be equally capable of multiplication in mouse peritoneal macrophages (PM) in vitro. The reproduction dynamics of TBE virus proved to be the same in PM of mice both highly sensitive and relatively less sensitive to TBE virus. The preliminary immunization of PM donors with commercial inactivated or experimental concentrated TBE virus vaccine produced no effect on the capacity of the virus for multiplication in PM. These facts indicate the absence of correlation between the capacity of the viruses under study for multiplication in PM in vitro and their virulence in vivo, as well as the insignificant role of circulating macrophages in the realization of the barrier function in an immune or nonimmune body.

[Concentrated purified vaccine against tick-borne encephalitis. An immunological evaluation in experiments on mice]. / Kontsentrirovannaia, ochishchennaia vaktsina protiv kleshchevogo étsefalita. Immunologicheskaia otsenka v opytakh na myshakh.

Comparative investigations of the immunological activity of two inactivated vaccines against tick-borne encephalitis, concentrated and commercial ones, were carried out. Higher levels of humoral and cellular immune responses were achieved after inoculation of the concentrated vaccine. Both vaccines did not affect the general immunological responsiveness of the animals.