ABSTRACT
Del 2071% de los pacientes con síndrome de Sjögren (SS) desarrolla manifestaciones sistémicas. Objetivos: El objetivo fue evaluar las características clínicoserológicas y frecuencia la de manifestaciones sistémicas en pacientes con SS primario. Material y métodos: Estudio retrospectivo con revisión de historias clínicas de pacientes con Sd de Sjögren primario visitados en el Hospital Británico de Buenos Aires en el período desde Enero de 2000 a Agosto de 2008. Resultados: Se incluyeron 41 paciente que cumplían criterios de clasificación Europeoamericanos 2002 para SS, todos de sexo femenino. La edad media fue 57,85±12,42 años (rango 2679). El tiempo de evolución fue de 9,28 años (rango 0,0824). Treinta y tres (80,49%) presentaron manifestaciones sistémicas. Las más frecuentes fueron artritis, vasculitis cutánea y polineuropatía. Este grupo presentó más frecuentemente títulos de AAN ≥1/640 e hipocomplementemia; aunque no estadísticamente significativas. La frecuencia de manifestaciones sistémicas halladas fue mayor a la reportada en otras series. Conclusiones: Un abordaje multidisciplinario enfocado en las manifestaciones sistémicas debería ser el nuevo estándar para el manejo del SS (AU)
Twenty to 71% of patients with Sjögren's syndrome (SS) will develop systemic manifestations. Objective: to characterize the clinical-serological presentation and the frequency of systemic manifestations in patients with primary SS. Methods: Retrospective study including patients with SS visited in Hospital Británico de Buenos Aires during the period from January 2000 to August 2008.Results: Forty-one patients fulfilled the 2002 American-European classification criteria for SS. All patients were women. Mean age at enrollment was 57,85±12,42 years (range 2679). Mean duration of the disease was 9,28 years (range 0,0824). Thirty-three (80,49%) developed systemic manifestations. The most frequent were arthritis, cutaneous vasculitis and polyneuropathy. This group featured more frequently ANA titles ≥1/640 and hypocomplementemia; although no statistical significance was found. The frequency of systemic manifestations found was greater than reported in the literature.Conclusions: A multidisciplinary approach focusing also on systemic manifestations should be the new standard for management of SS (AU)
Subject(s)
Humans , Male , Female , Middle Aged , Sjogren's Syndrome/complications , Sjogren's Syndrome/diagnosis , Sjogren's Syndrome/therapy , Polyneuropathies/complications , Polyneuropathies/diagnosis , Autoimmunity/immunology , Xerostomia/complications , Xerostomia/diagnosis , Argentina/epidemiology , Retrospective Studies , Medical Records/statistics & numerical data , Connective Tissue/pathology , Connective TissueABSTRACT
UNLABELLED: Twenty to 71% of patients with Sjögren's syndrome (SS) will develop systemic manifestations. OBJECTIVE: To characterize the clinical-serological presentation and the frequency of systemic manifestations in patients with primary SS. METHODS: Retrospective study including patients with SS visited in "Hospital Británico de Buenos Aires" during the period from January 2000 to August 2008. RESULTS: Forty-one patients fulfilled the 2002 American-European classification criteria for SS. All patients were women. Mean age at enrollment was 57.85 ± 12.42 years (range 26-79). Mean duration of the disease was 9.28 years (range 0.08-24). Thirty-three (80.49%) developed systemic manifestations. The most frequent were arthritis, cutaneous vasculitis and polyneuropathy. This group featured more frequently ANA titles ≥ 1/640 and hypocomplementemia; although no statistical significance was found. The frequency of systemic manifestations found was greater than reported in the literature. CONCLUSIONS: A multidisciplinary approach focusing also on systemic manifestations should be the new standard for management of SS.
ABSTRACT
INTRODUCTION: The daily press is an important source of health information and may influence health care utilization. However, medical reports published in newspapers from developed countries have shown a poor quality. OBJECTIVES: The reliability of the questionnaire Index of Scientific Quality was evaluated by using it to measure the scientific quality of health information published by Argentinian newspapers between 2000 and 2002. It assessed the readability of the texts in grade levels and explored the relationship between quality and other factors. MATERIALS AND METHODS: The Spanish adaptation of the instrument consisted in translation, back-traslation and pilot study. The reliability was assessed by applying the instrument to newspaper articles with more than 300 words that discussed therapy, diagnosis, prevention, lifestyle effects, and hazardous exposure. Two physicians independently graded 129 articles. Inter-observer and intra-observer concordance was quantified for each item with the intra-class correlation coefficient (CI95%). To measure scientific quality, a randomized sample of 210 articles was assessed. Each received a mark that ranged from 0 to 100. Readability was determined by the FRY graph method. The relationship between quality and other variables was explored with multiple linear regression analysis. RESULTS: The inter-rater concordance varied between 0.48 (0.34-0.61) and 0.67 (0.56-0.75). Intra-rater concordance varied from 0.51 (0.37-0.63) to 0.95 (0.93-0.96). The internal consistency (Cronbach's alpha) was 0.88. The quality-of-health-information was rated at 25 points (16.7, 33.3) [median (intercuartil range)]. The reading level was assessed to be at the 10.4 grade (10.2-10.6) [mean (CI 95%)]. CONCLUSIONS: Quality of the health information was greatly deficient; however, no specific factors were related with quality. Readability was probably a key barrier for access to the health information.
Subject(s)
Journalism, Medical/standards , Newspapers as Topic , Reproducibility of Results , Surveys and Questionnaires , Argentina , Comprehension , Health Education , Humans , Surveys and Questionnaires/standards , TranslationsABSTRACT
Introducción. La prensa diaria constituye una fuente de acceso a la información de salud y puede influenciar sobre la utilización de servicios sanitarios. La calidad de las noticias publicadas en periódicos de países desarrollados es subóptima. Objetivo. Adaptar al castellano y evaluar la confiabilidad del cuestionario Index of Scientific Quality; medir la calidad de la información de salud publicada en la prensa diaria argentina durante los años 2000 a 2002; determinar el nivel de lectura requerido (en grados de escolarización) para comprender los textos; analizar los factores asociados a la calidad. Materiales y métodos. La adaptación consistió en la traducción del Index of Scientific Quality, retrotraducción y prueba piloto. Para la confiabilidad, se seleccionaron artículos con más de 300 palabras referidos a tratamiento, prevención, diagnóstico, efectos del estilo de vida y exposiciones peligrosas sobre la salud. Dos médicos calificaron independientemente 129 artículos. Se cuantificó la concordancia interobservador e intraobservador para cada ítem mediante el coeficiente de correlación intraclase (IC95 por ciento). La calidad se evaluó en 210 artículos seleccionados al azar. Se asignaron valores entre 0-100 puntos. El nivel de lectura se evaluó mediante el método gráfico de FRY. Se exploró la relación entre calidad y otras variables mediante un modelo de regresión lineal múltiple. Resultados. La concordancia interobservador osciló entre 0,48 (0,34-0,61) y 0,67 (0,56-0,75); la concordancia intraobservador entre 0,51 (0,37-0,63) y 0,95 (0,93-0,96); la consistencia interna (alfa de Cronbach), 0,88; la calidad mediana(rango intercuartílica)=25 puntos (16,7 y 33,3), y el nivel de lectura [promedio (IC95 por ciento)]=10,4 grados (10,2 y 10,6). Conclusiones. La calidad de la información fue deficitaria. No se encontraron factores que expliquen la baja calidad. El nivel de lectura resultó una barrera de acceso a la información
