ABSTRACT
The directed influence of immunomodulators on various chains of the immune system makes possible the control over liver restoration processes, as demonstrated on the model of hepatic resection. It is established that macrophages together with T-lymphocytes play a very important role in the process of liver regeneration.
Subject(s)
Immunologic Factors/pharmacology , Liver Regeneration/drug effects , Liver/drug effects , Animals , Hepatectomy , Liver/cytology , Liver/immunology , Liver Regeneration/immunology , Macrophages/drug effects , Male , Mitotic Index , Organ Size/drug effects , Rats , T-Lymphocytes/drug effects , Time FactorsABSTRACT
Donor splenocytes and timocytes have an ability to stimulate erythropoesis after massive blood-letting. Changing of functional state of the immune system by means of immune modulators action affects the character and expressiveness of hemopoiesis regulation function of lymphocytes. Splinocytes and thymocytes depress granulocytopoiesis in the recipients' bone marrow after activation by T- and B-lymphocytes. The activation of B-lymphocytes determines the cells' capacity to increase concentration of thrombocytes in the blood. Donor thymocytes can activate erythropoiesis and granulocytopoiesis after macrophages stimulation.
Subject(s)
Hematopoiesis/physiology , Lymphocyte Activation/immunology , Lymphocytes/immunology , Adjuvants, Immunologic/pharmacology , Animals , Bone Marrow Cells/immunology , Erythrocyte Count , Hemorrhage/immunology , Lymphocyte Activation/drug effects , Lymphocytes/drug effects , Macrophages/drug effects , Macrophages/immunology , Male , Organic Chemicals , Rats , Rats, Inbred Strains , Spleen/cytology , Spleen/immunology , Thymus Gland/cytology , Thymus Gland/immunology , Thymus Hormones/pharmacologyABSTRACT
The formation of blood system adoptive reaction in many cases is defined by the type of action and the condition of hemopoietic inductive microenvironment: hemodynamics of hemopoietic tissue, functional conditions of bone marrow macrophages, mast cells and glycosaminoglycans content. The shift in hemodlobin fraction occurs in extreme conditions requiring an increased gas transport by the blood. In case of tissue lesion, lymphocytes stimulate their regeneration. Morphogenetic function of lymphoid cells may be alerted by immunomodulators. Blood cells participate in angiogenesis, and this property may be used for vessel grafts production.
