[Changes in the properties of the brain opiate, DA2, GABA, and 5-HT1 receptors in the progeny of female rats consuming ethanol for a long time during pregnancy and lactation]. / Izmenenie svoistv opiatnykh, DA2-, GAMK- i 5HT1-retseptorov mozga u potomkov krys-samok, dlitel'no potrebliavshikh étanol vo vremia beremennosti i laktatsii.

The study was undertaken to examine two-week and two-month rats whose mothers had been given alcohol for a long period of time during pregnancy and lactation. Profound changes were found in the properties of all types of the receptors under study. The changes were found in the receptors of both group animals. Substantial changes were encountered in the properties of GABA and DA2 receptors in the brain of two-month rats after acute alcoholization. The changes were differentiated from those seen in GABA and DA2 receptors in the brain of the rats whose mothers had not been given ethanol.

[The biological mechanisms of a congenital predisposition to alcoholism]. / Nekotorye biologicheskie mekhanizmy vrozhdennoi predraspolozhennosti k alkogolizmu.

In descendants of white rats with chronic alcoholic intoxication, the contents of DA in the brain and blood plasma, characteristics of GABA and opiate brain receptors, the contents of cAMP and other substances were studied as well as the c-fos gene expression. The data obtained suggest a considerable role of the changes in the DA system functions in the genesis of pathology in these descendants.

[Changes in the properties of the 5-HT1 receptors in the brains of rats, the progeny of parents consuming morphine for a long time]. / Izmenenie svoistv 5-HT1-retseptorov mozga u krys--potomkov roditelei, dlitel'no potrebliavshikh morfin.

Studies were performed in two-month rats whose parents had been given morphine for a long period before mating. Considerable changes were found in the properties of rat brain 5-HT1 receptors, which manifested as increased number of ligand binding sites (Bmax) and higher KD, which indicates a lower receptor affinity for ligand. Single morphine administration to the animals caused normalization of the properties of the receptors.

[The action of low doses of bromocryptin in experimental morphine abstinence in rats]. / Deistvie malykh doz bromokriptina pri éksperimental'noi morfinnoi abstinentsii u krys.

In experiments on rats which consumed for a long time morphine solution as a drinking liquid there was studied the effect of low doses of bromocriptine on the behavioural manifestations of morphine abstinence syndrome and the condition of the noradrenergic, dopaminergic and conjugated GABAergic systems of the brain. It was shown that the preliminary administration of bromocriptine decreased the degree of the withdrawal syndrome that correlated with the restoration of dopamine content and the normalization of the condition of D2-dopaminergic receptors in different regions of the brain. Bromocriptine exerted no influence on the morphine withdrawal-induced changes in the condition of GABA receptors of the cerebral cortex.

[Effect of bromocryptin on the alcohol consumption and catecholamine level in the brain of rats undergoing long-term alcoholization]. / Vliianie bromokriptina na potreblenie alkogoloa i uroven' katekholaminov v mozge krys v usloviiakh dlitel'noi alkogolizatsii.

It has been established in experiments on rats subjected to long-term alcoholization that chronic administration of bromocryptin in small doses (1 mg/kg) considerably minimizes ethanol consumption by animals. Reduction in alcoholic motivation correlates with normalization of the level of dopamine, decreased by chronic alcohol action in the rat hypothalamus and midbrain. The use of bromocryptin also prevents an increase in the dopamine content in the rat hypothalamus during alcohol withdrawal.

[Effect of cholecystokinin on dopamine metabolism in the rat brain]. / Vliianie kholetsistokinina na omen dofamina v mozge krys.

The effect of sulfated octapeptide of cholecystokinin (CCK) on dopamine turnover was examined in different parts of the rat brain. It was demonstrated that CCK administered intrapeutoneally in doses of 5, 15 and 30 micrograms/kg significantly increased dopamine turnover in the amygdala, and nucleus accumbeus, without changing dopamine turnover in the midbrain, hypothalamus and striatum. The data suggest that variation in the activity of the mesolimbic dopamine system might be one of the mechanisms by which CCK regulates the animals behavior.

[Neurochemical basis of the pathogenesis of different types of addiction]. / Neirokhimicheskie osnovy patogeneza razlichnykh tipov narkomanii.

The study is concerned with the influence of narcotic drugs of a different chemical nature (alcohol, morphine, barbamil) on the catecholamine metabolism in some areas of the brain and adrenal gland in experimental animals. Each of the studied drugs exerted a differentiated effect on the catecholamine system in the different brain structures. However all these substances both in a single administration and in a long-term use, and development of a drug dependence, evoked similar changes in the catecholamine metabolism in the hypothalamus and in the middle brain. These changes were shown by an intensified release and destruction of the noradrenalin neuromediator under the influence of the above-mentioned substances and a compensatory increases in the catecholamine synthesis on a prolonged use. Withdrawal of narcotic drugs leads to a significant increase in the dofamine level in these brain areas. The pharmacological analysis demonstrated, that the formation of a narcotic dependence may be connected with the changed functions of the catecholamine brain system.