ABSTRACT
We studied effects of a new drug with nootropic action nooglutil (N-(5-hydroxynicotinoil)-L-glutaminic acid, OHK-10) on initial stages of different forms of operant behaviour in rats, namely avoidance learning in Shuttle box, in Skinner box and on T-maze reflex with water reward. Comparing dates resulted from these three methods permitted evaluation of effects of the drugs on learning. Both drugs had no effects on avoidance response in shuttle box and T-maze reflex with water reward. Nooglutil enhanced escape and avoidance responses meanwhile piracetam improved only escape response.
Subject(s)
Conditioning, Operant/drug effects , Glutamates/pharmacology , Nicotinic Acids/pharmacology , Piracetam/pharmacology , Psychotropic Drugs/pharmacology , Animals , Drinking Behavior/drug effects , Escape Reaction/drug effects , Male , Rats , Reinforcement, PsychologyABSTRACT
Administration of ethanol (5 g/kg/day, per os) to the pregnant rats evoked delayed impairments of the learning and memory in the offspring. Prenatal alcoholization of the animals attenuated the habituation of the exploration behavior in open field, impaired acquisition and retention of active avoidance in a shuttle box, increased slow activity of the EEG spectrum power, disturbed the function of the serotoninergic system in the brain cortex and of the dopaminergic system in the hippocamp. The new nootropic drug nooglutyl (N-5/hydroxynicotinoyl/-L-glutamic acid) administered in a dose of 25 mg/kg/day from the 8th to the 20th day of life prevented the above-mentioned delayed disturbances of higher integrative functions and biochemical processes in rat brain.
Subject(s)
Central Nervous System Diseases/drug therapy , Ethanol/toxicity , Glutamates/therapeutic use , Nicotinic Acids/therapeutic use , Prenatal Exposure Delayed Effects , Psychotropic Drugs/therapeutic use , Animals , Behavior, Animal/drug effects , Brain/drug effects , Brain/physiopathology , Brain Chemistry/drug effects , Central Nervous System Diseases/chemically induced , Central Nervous System Diseases/physiopathology , Drug Evaluation, Preclinical , Female , Glutamates/pharmacology , Higher Nervous Activity/drug effects , Male , Nicotinic Acids/pharmacology , Pregnancy , Psychotropic Drugs/pharmacology , RatsABSTRACT
The psychopharmacological activity of a new compound--ONK-10--N-5(hydroxynicotinoyl)-L-glutamic acid was studied. It was shown in experiments on mice and rats that the compound possesses the pronounced antiamnestic and antihypoxic effects, does not disturb the conditioned reflex activity and the orientation behavior, has no anxiolytic activity and anticonvulsant properties, causes no disorder of movement coordination, is low toxic. ONK-10 is superior by its antiamnestic and antihypoxic effects to piracetam, meclophenoxat, demanol aceglumate and is not inferior to aniracetam.
Subject(s)
Glutamates/pharmacology , Nicotinic Acids/pharmacology , Psychotropic Drugs/pharmacology , Amnesia/drug therapy , Animals , Anti-Anxiety Agents/pharmacology , Anti-Anxiety Agents/therapeutic use , Avoidance Learning/drug effects , Conditioning, Classical/drug effects , Drug Evaluation, Preclinical , Glutamates/therapeutic use , Hypoxia/drug therapy , Male , Mice , Muscle Relaxants, Central/pharmacology , Muscle Relaxants, Central/therapeutic use , Nicotinic Acids/therapeutic use , Psychotropic Drugs/therapeutic use , RatsABSTRACT
The comparative study of the psychotropic activity of new acyl derivatives of dibenzazepine and phenothiazine--bonnecor (chlorhydrate 3-carbethoxyamino-5(dimethylaminoacetyl) dibenzazepine and ethacizine (chlorhydrate 2-carbethoxyamino-10-(beta-diethyl-aminopropionyl)phenothiazine)--in the experiments on small laboratory animals showed the presence of the antidepressive, anxiolytic, antiamnesic and antihypoxic effects. The drugs exerted the psychotropic effects at administration in the doses exceeding those which influence the cardiovascular system. By the degree of the anxiolytic action bonnecor and ethacizine are inferior to diazepam, are as potent as trioxasine and are superior to meprobamat. The noted psychotropic action by its character and degree can serve as a beneficial supplement to the spectrum of the pharmacological activity of the studied compounds.
Subject(s)
Dibenzazepines/pharmacology , Phenothiazines/pharmacology , Psychotropic Drugs/pharmacology , Amnesia/drug therapy , Animals , Anti-Anxiety Agents , Anti-Arrhythmia Agents/pharmacology , Antidepressive Agents , Dose-Response Relationship, Drug , Hypoxia/drug therapy , Male , Mice , Rats , Structure-Activity RelationshipABSTRACT
In experimental studies on mice it was shown that piracetam, Cleregil, centrophenoxine, pyritinol possessed the most pronounced anti-amnestic activity. A close effect was noted with Euclidan, 3-hydroxypyridine and ionol. GABAergic agents (sodium oxybutyrate, phenibut, pantogam), gutimine, nicotinoyl-GABA eliminated amnesia to a lesser extent. The antihypoxic effect on the model of hypobaric hypoxia was exerted by typical antihypoxic agents (gutimine, sodium oxybutyrate, 3-hydroxypyridine). The antihypoxic activity of nootropic drugs (centrophenoxine, pyritinol, phenibut) could be determined only at a significant increase of doses. No interrelationship and the presence of dissociation in manifestation of anti-amnestic and antihypoxic effects were revealed.
