[Effect of the orbitofrontal area of the cat cerebral cortex on the resistance of the supraoptical nuclei of the hypothalamic region under ftorotan anesthesia]. / Vliianie orbitofrontal'noi zony kory bol'shogo mozga koshki na ustoichivost' nadzritel'nykh iader podbugornoi oblatsi v usloviiakh ftorotanovogo narkoza.

Acute experiments have shown that as ftorotan anesthesia is enhanced, the supraoptical nucleus of the hypothalamic area deprived of the effect of the orbitofrontal zone of the cerebral cortex gets less resistant to ftorotan than the analogous nucleus experiencing the influence of the cortical zones. The greatest resistance to ftorotan anesthesia was displayed by the orbitofrontal zone of the cortex. In the course of the animals' egress from anesthesia, the bioelectrical activity got recovered in the following way: first in the orbitofrontal zone of the cortex, then in the supraoptical nuclei of the hypothalamic area that retained the influence of the cortex, and, finally, in the supraoptic nuclei deprived of the subordination effect of the cortex.

[Effect of the orbitofrontal zone of the cat cerebral cortex on the resistance of the supraoptic nuclei of the hypothalamus to ether]. / Vliianie orbitofrontal'noi zony kory kol'shogo mozga koshki na ustoichivost' nadzritel'nykh iader podbugornoi oblasti po otnosheniiu k éfiru.

Acute experiments on cats have shown that with an increase of ether anesthesia, the supravisual nucleus of the hypothalamus deprived of the influence of the orbitofrontal zone of the cerebral cortex gets less resistant to ether than an analogous nucleus that retained the subordination influence of the cortex. The highest resistance is demonstrated by the orbitofrontal zone of the cortex under conditions of ether anesthesia. In the course of the animal's wake up from anesthesia-induced sleep there takes place a recovery of bioelectrical activity primarily of the orbitofrontal zone of the cortex followed by the recovery of the supravisual nucleus which is under the cortex effect and finally of the supravisual nucleus deprived of the subordination effects of the cortex.

[Pharmacological properties of a new benzimidazole derivative]. / O farmakologicheskikh svoistvakh novogo proizvodnogo benzimidazola.

The pharmacological action of the new benziamidazole derivative 1-(3-diethylamino-2-oxypropyl)-2-propylbenzimidazole (abazol) was studied in experiments on mice, dogs, cats and isolated ears of rabbits. In cats and dogs, abazol produces a hypotensive effect and transient reduction of the EEG wave amplitude. Abazol dilates the vessels of an isolated rabbit ear. It shows less toxicity and less pronounced convulsant effect as compared to dibazol.

[Comparative intensity of oxidative phosphorylation in different regions of the cerebral cortex of intact animals during anesthesia and hypoxia]. / Sravnitel'naia intensivnost' okislitel'nogo fosforilirovaniia v razlichnykh otdelakh kory golovnogo mozga intaktnykh zhivotnykh v usloviiakh narkoza i gipoksii.

Experiments on 54 dogs with the use of the manometric method of Warburg proved that the level of oxidative phosphorylation in the brain cortex segments differing in the level of their phylogenic development is dissimilar. In the new cortex segment (sensomotor region) the oxygen and inorganic phosphorus uptake as well as the degree of their conjugation, as compared to the energy exchange intensity in the tissues of the old cortex (hippocampus), were found to show a higher level. Anesthetics, such as ether and sodium hexobarbital caused dissociation of the oxidative phosphorylation, more pronounced in the elements of the old cortical segments than in the new ones. The suppression of biochemical processes was especially profound under the effect of sodium hexobarbital and less marked under an ether poisoning. Hypoxia and combined action of an anesthetic and hypoxia produced inhibition of the energy exchange, more intensive in the new cortical segments.

[The influence of fluothane and hexobarbital on the cerebral cortex and spinal cord centers]. / Bliianie ftorotana i Geksenala na kiru bol'shikh polusharii i tsentry shinnogo mozga.

Tests set up on 17 cats demonstrated by using methods of evoked potentials that the reflex activity of the spinal cord centers is inhibited after introduction of 2.3 +/- 0.2 ml of fluothane, whereas the functional performance capacity of the large hemispheres cortex is suppressed following administration of 3,2 +/- 0,8 ml of the drug. The restitution of excitability and conductivity of the cortex in the post-anesthetization period proceeds at the rate 1.7 times faster than the restoration of the spinal cord centers. With deepening of the hexobarbital anesthesia complete inhibition of the spinal reflex activity supervenes after introduction of 56.3 +/- 12.3 ml/kg and that of the cortex following introduction of 115.0 +/- 23.2 ml/kg of hexobarbital.

[Comparative reactivity of the neo-, paleo- and archicortex of the brain under conditions of ether and hexanal anesthesia]. / Sravnitel'naia reaktivnost' novoi, staroi i drevnei kory golovnogo mozga v usloviiakh éfirnogo i geksenalovogo narkoza

In acute experiments on dogs subject to investigation under ether- and hexobarbital sodium-induced anesthesia was comparative reactivity of the neo-(sensomotor region), paleo-(hippocampus) and archicortex (olfactory lobe) of the brain. It was found that following administration of low and medium doses of general anesthetics more marked EEG changes, with but an insignificant inhibition of respirations and a slight fall in arterial pressure, were observed to occur in the hippocampus and in the olfactory lobe, as against the biocurrents in the sensomotor region. Such a regularity continued for as long as the oxygen tension in the neocortex was maintained at a level higher than in the paleo-and archicortex. Upon introduction of toxic ether and hexobarbital doses the oxygen tension in the neocortex dropped earlier and the inhibition of its bioelectric activity would set in concurrently or sooner than in the olfactory lobe and in the hippocampus.

[Comparative effect of ether, chloroform and fluothane on brain cortical neurons]. / O sravnitel'nom vliianii éfira, khloroforma i ftorotana na neirony kory golovnogo mozga

In tests staged on 35 cats it was established that chloroform and fluothane display the biological activity which is 5 times as high as that of ether with respect to the brain cortex neurons. The reactive properties of individual neurons of the brain cortex are dissimilar and this, other conditions of anesthetization being equal, determines their unequal resistance to the action of anesthetics.