ABSTRACT
A differentiated approach is substantiated toward treatment with aethonium (antibacterial, antiinflammatory, antioxidant drug preparation) of chronic pancreatitis with special reference to the status of lipid peroxidation, glutathionic link of antioxidant defence, and exocrine function of the pancreas (season-related rhythm of its activity), in different forms and degrees of severity included.
Subject(s)
Anti-Infective Agents/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Antioxidants/therapeutic use , Pancreas/metabolism , Pancreatitis/drug therapy , Pancreatitis/physiopathology , Quaternary Ammonium Compounds/therapeutic use , Seasons , Adult , Antioxidants/metabolism , Chronic Disease , Female , Humans , Lipid Peroxidation/drug effects , Male , Middle Aged , Pancreas/drug effects , Pancreas/enzymology , Pancreatitis/enzymology , Recurrence , SteroidsABSTRACT
Changes were studied in the clinical picture and microecological setting of the large intestine in elderly and old patients with chronic bronchitis (n = 17) against the background of antibacterial therapy that leads to the development of dysbacteriosis, including that with increased content of Candida. Shown in elderly and old patients with chronic bronchitis is efficacy of the outlined treatment option for the prophylaxis of candidiasis type dysbacteriosis (diphlucan, linaex, decamevite, nitroxoline).
Subject(s)
Bacterial Infections/prevention & control , Bronchitis/drug therapy , Candidiasis/prevention & control , Aged , Bacterial Infections/drug therapy , Bacterial Infections/microbiology , Bronchitis/complications , Bronchitis/microbiology , Candidiasis/drug therapy , Candidiasis/microbiology , Chronic Disease , Drug Therapy, Combination , Female , Humans , Intestines/microbiology , Male , Middle Aged , Time FactorsABSTRACT
A total of 252 patients were examined. It has been shown that forms of chronic pancreatitis (ChP) have some distinguishing features of the clinical course of the disease and depend on morphofunctional state of pancreas, its ecbolic activity, degree of microcirculatory disorders, state of lipid peroxidation (LPO), that of the antioxidant system of defence as well as psychophysiologic status of the personality, circadian and seasonal variability of functional activity of pancreas in patients with chronic pancreatitis. Substantiated in the paper is rehabilitative staged treatment of ChP patients, depending on ChP forms with due regard to the above-mentioned mechanisms of its relapse, most important of which is LPO status, that of antioxidant system of defence and microcirculation.
