ABSTRACT
1-[(3-chlorophenyl)phenylmethyl]urea--a compound possessing anticonvulsant activity, which has been selected by screening among 100 linear and cyclic urea derivatives, produces synchronization of spontaneous bioelectric activity, increased convulsion threshold in the motor cortex, dorsal hippocampus, and basolateral nuclei of amygdala, increased the index of low-frequency flicker acquisition, and reduced response to high-frequency oscillations in the visual cortex of rabbits. This compound also increased the extracellular content of sodium ions and reduced intracellular content of potassium ions in the motor cortex, dorsal hippocampus, and amygdala.
Subject(s)
Anticonvulsants/pharmacology , Evoked Potentials, Motor/drug effects , Evoked Potentials, Visual/drug effects , Seizures/prevention & control , Urea/analogs & derivatives , Animals , Basolateral Nuclear Complex/drug effects , Basolateral Nuclear Complex/metabolism , Basolateral Nuclear Complex/physiopathology , Cations, Monovalent , Electric Stimulation , Female , Hippocampus/drug effects , Hippocampus/metabolism , Hippocampus/physiopathology , Ion Transport/drug effects , Male , Microelectrodes , Motor Cortex/drug effects , Motor Cortex/metabolism , Motor Cortex/physiopathology , Photic Stimulation , Potassium/metabolism , Rabbits , Seizures/metabolism , Seizures/physiopathology , Sodium/metabolism , Stereotaxic Techniques , Urea/pharmacology , Visual Cortex/drug effects , Visual Cortex/metabolism , Visual Cortex/physiopathologyABSTRACT
CIA, ferritin, ACTH, cortisol, TTH, T3, T4, insulin, CT and PTH levels were assayed radioimmunologically in the blood serum of 227 patients with lung cancer, stages I-IV, 134 cases of chronic nonspecific diseases of the lung, 28 patients with benign tumors of the lung and 30 healthy subjects. Adrenaline tests were carried out in 160 of them. Similar shifts were observed in hormone profile in both cancer and non-cancer patients. The predictive value of the hormone tests for stage I-II cancer appeared higher than in those for CIA and ferritin. However, the diagnostic value of a single test of marker proved insufficient for its practical use. Adrenaline tests identify fine disturbances in endocrine regulation and considerably raise the predictive value of such indicators as ACTH, insulin, TTH, T3, T4 and calcitonin. To assure high effectiveness of the use of basic radioimmunological data, a combination of indexes should be prepared for each case, and it should include, apart from basic levels of markers, their post-test values and indexes of reactivity.
Subject(s)
Biomarkers, Tumor/blood , Epinephrine , Hormones/blood , Lung Neoplasms/diagnosis , Adenocarcinoma/blood , Adenocarcinoma/diagnosis , Adenocarcinoma/pathology , Carcinoma, Large Cell/blood , Carcinoma, Large Cell/diagnosis , Carcinoma, Large Cell/pathology , Carcinoma, Small Cell/blood , Carcinoma, Small Cell/diagnosis , Carcinoma, Small Cell/pathology , Carcinoma, Squamous Cell/blood , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/pathology , Epinephrine/administration & dosage , Humans , Injections, Subcutaneous , Lung Diseases, Obstructive/blood , Lung Diseases, Obstructive/diagnosis , Lung Neoplasms/blood , Lung Neoplasms/pathology , Neoplasm Staging , RadioimmunoassayABSTRACT
Radioimmunoassay of 12 hormones, carcinoembryonic antigen and ferritin in blood serum was carried out in 140 subjects at high risk for lung cancer. The study group included males aged more than 50 with a questionnaire-based record of smoking for more than 20 years. 140 patients with stage I-III lung tumors and 40 healthy subjects were in control. The profile and trends of hormonal shifts in those at risk and stage I-III lung cancer patients proved identical but were significantly different from the same parameters in healthy subjects. In the group at risk, endocrine disorders were more pronounced than the rise in tumor marker levels.
