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[Recruitment of angiotensin receptors by concanavalin A in the rabbit aorta]. / Recrutement des récepteurs de l'angiotensine par la concanavaline A dans l'aorte de lapin.

Khullar, H; Palaic, D; Farrugia, P.

Union Med Can ; 116(2): 80-2, 85, 1987 Feb.

Article in French | MEDLINE | ID: mdl-3564189

Subject(s)

Concanavalin A/pharmacology , Muscle, Smooth, Vascular/drug effects , Receptors, Angiotensin/drug effects , Animals , Aorta/drug effects , Aorta/metabolism , In Vitro Techniques , Male , Muscle, Smooth, Vascular/metabolism , Rabbits

Effect of colchicine on angiotensin receptors in rabbit aorta.

Palaic, D; Farruggia, P; Khullar, H.

J Cardiovasc Pharmacol ; 3(4): 876-80, 1981.

Article in English | MEDLINE | ID: mdl-6167817

ABSTRACT

Colchicine (10(-5) M) significantly depressed the dose-response curve for angiotensin in isolated rabbit aortic strips. A lower maximal response was observed without apparent change in receptor affinity for angiotensin, as can be judged by unchanged ED50 values. Colchicine also diminished the dose-response curve for norepinephrine. The angiotensinase activity in cell membrane fraction and high-speed supernate was significantly inhibited. Colchicine did not change the specific receptor binding of radioactive angiotensin to either cell membrane fraction or supernate. It is concluded that colchicine possibly depresses the response to angiotensin through a mechanism involving a site beyond membrane receptors.

Subject(s)

Colchicine/pharmacology , Muscle, Smooth, Vascular/drug effects , Receptors, Angiotensin/drug effects , Receptors, Cell Surface/drug effects , Angiotensin II/pharmacology , Animals , Aorta/drug effects , Cell Membrane/metabolism , Female , In Vitro Techniques , Muscle Contraction/drug effects , Muscle, Smooth, Vascular/metabolism , Norepinephrine/pharmacology , Rabbits

Subject(s)

ABSTRACT

Subject(s)

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