1.
J Org Chem
; 71(7): 2811-9, 2006 Mar 31.
Article
in English
| MEDLINE
| ID: mdl-16555836
ABSTRACT
We present a convenient synthesis of novel heteroaryl-fused 3-oxo-1,4-thiazepine-5-carboxamides and 5-oxo-1,4-thiazepine-3-carboxamides using a modification of four-component Ugi condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds and discuss the scope and limitations of the chemistry involved.