ABSTRACT
Using experimental and clinical methods, the authors studied the efficacy of combined use of anticonvulsants (phenobarbital, hexamidine, chloracon, trimetin, benzonal, diphenylhydantoin, carbamazepine) and tranquilizers (diazepam, chlordiazepoxide, meprotan, trioxazine, mebicar) in epilepsy treatment. The experimental findings showed that 13 combinations of the above drugs had a synergic effect. Five of these combinations (hexamidine-chlordiazepoxide, benzonal-chlordiazepoxide, phenobarbital-diazepam, phenobarbital-trioxazine, and phenobarbital-mebicar also proved clinically more effective than the use of anticonvulsants alone.
Subject(s)
Anticoagulants/therapeutic use , Tranquilizing Agents/therapeutic use , Adolescent , Adult , Animals , Anticoagulants/toxicity , Dogs , Drug Evaluation , Drug Evaluation, Preclinical , Drug Synergism , Drug Therapy, Combination , Drug Tolerance , Epilepsy/drug therapy , Female , Humans , Male , Mice , Middle Aged , Rats , Seizures/drug therapy , Tranquilizing Agents/toxicityABSTRACT
Effects of anticonvulsants (phenobarbital, hexamidine, benzonal, difenin, chloracon, trimetin, carbamazepine) on the psychotropic activity of tranquillizers (diazepam, chlordiazepoxide, meprotan, trioxazine, mebicar) were studied in experiments on mice and rats. Thirteen combinations were studied by using corazol test, "open field" and elementary-defensive conditioned response technique. According to all three tests the psychotropic activity was enhanced to the greatest degree by administration of hexamidine in combination with chlordiazepoxide.
Subject(s)
Anticonvulsants/pharmacology , Mental Processes/drug effects , Tranquilizing Agents/pharmacology , Animals , Conditioning, Classical/drug effects , Drug Interactions , Escape Reaction/drug effects , Female , Male , Mice , Orientation/drug effects , Pentylenetetrazole/antagonists & inhibitors , RatsABSTRACT
Experiments on mice were made to study anticonvulsive activity of the combinations of 5 tranquilizers (diazepam, chlorodiazepoxide, meprotan, trioxazin, mebicar) and 7 anticonvulsants (phenobarbital, hexamidine, benzonal, diphenin, chloracon, trimetin, carbamazepin) according to the maximal electroshock test. The data obtained form an experimental basis for the combined use of some anticonvulsants and tranquilizers in the treatment of epilepsy, since in a number of cases these combinations permit a significant lowering of the doses of both components without reducing their anticonvulsant activity.
