ABSTRACT
Malignant transformation has been described in 30% of cases of giant anorectal condyloma acuminatum. The authors report on a 33-year-old man who was heterosexual and HIV negative and who had a giant anal condyloma. Despite aggressive therapy with multiple fulgurations, interferon alpha and isotretinoin, an invasive squamous cell carcinoma of the rectum developed. An abdominoperineal resection was done followed by radiotherapy and chemotherapy, but this treatment regimen was unsuccessful in controlling the progression of his carcinoma. Human papillomavirus (HPV) serotyping in tumoral tissue was positive for HPV types 11 and 16. In patients with giant anorectal condylomas associated with oncogenic HPV, the course of the disease may be aggressive, so they may benefit from early surgical and medical intervention.
Subject(s)
Anus Diseases/therapy , Condylomata Acuminata/therapy , Rectal Diseases/therapy , Adult , Anus Diseases/complications , Carcinoma, Squamous Cell/etiology , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Combined Modality Therapy , Condylomata Acuminata/complications , Fatal Outcome , HIV Seronegativity , Humans , Male , Precancerous Conditions/etiology , Precancerous Conditions/pathology , Precancerous Conditions/surgery , Rectal Diseases/complications , Rectal Neoplasms/etiology , Rectal Neoplasms/pathology , Rectal Neoplasms/surgery , Sexuality , Time FactorsABSTRACT
Cell-mediated immunity (CMI) of lung cancer patients to autologous tumor antigens was assessed by mixed lymphocyte tumor interactions (MLTI) as measured in a microculture (200 microliter) lymphocyte proliferation (LP) assay. Positive lymphoproleferative responses were observed with cryopreserved intact mitomycin-C-treated autologous tumor cells (8/12 or 67% patients reactive) and with hypotonic membrane extracts (HMP) of tumor cells (28/40 or 70%). Good correlation was found between reactivity to tumor cells and extracts in parallel testing. In contrast, HMP of autologous normal lung tissue elicited very little LP reactivity, with only one patient giving a weak response by the SI criterion and low level of n cpm. Upon repeat testing, many patients gave reproducibly positive LP responses to tumor HMP. Patients at all clinical stages of disease and with different histologic tumor types had a similar proportion of HMP reactivity. Most reactive patients responded to a broad range of protein concentrations of tumor HMP, and LP responses were frequently elicited with 1 microgram or less of HMP. Thus, HMP appear to afford a convenient source of reactive tumor antigen for assessing anti-tumor immunity.
Subject(s)
Antigens, Neoplasm , Immunity, Cellular , Lung Neoplasms/immunology , Adenocarcinoma/immunology , Carcinoma/immunology , Carcinoma, Small Cell/immunology , Carcinoma, Squamous Cell/immunology , Cell Membrane/immunology , Humans , Lymphocyte Activation , Lymphocyte Culture Test, Mixed , Lymphocytes/immunologyABSTRACT
Six patients with recurrent bladder papillomata were treated both by abdominal scarification with bacillus Calmette-Guérin (BCG) and by intravesical BCG, without resection. Four patients responded favorably (two showing major systemic complications), and the other two, who failed to respond, underwent further surgery.
Subject(s)
BCG Vaccine/therapeutic use , Papilloma/therapy , Urinary Bladder Neoplasms/therapy , Adult , Aged , Clinical Trials as Topic , Drug Evaluation , Female , Humans , Male , Middle Aged , RecurrenceSubject(s)
Antigens, Neoplasm/isolation & purification , Hypersensitivity, Delayed , Neoplasms/immunology , Breast Neoplasms/immunology , Cells, Cultured , Colonic Neoplasms/immunology , Epitopes , Female , Humans , Intradermal Tests , Lung Neoplasms/immunology , Melanoma/immunology , Neoplasms, Experimental/immunology , Sarcoma/immunologySubject(s)
Colonic Neoplasms/therapy , Rectal Neoplasms/therapy , Colonic Neoplasms/mortality , Colonic Neoplasms/surgery , Fluorouracil/therapeutic use , Humans , Immunosuppressive Agents/therapeutic use , Neoplasm Metastasis , Nitrosourea Compounds/therapeutic use , Rectal Neoplasms/mortality , Rectal Neoplasms/surgery , Thiotepa/therapeutic useABSTRACT
Emphysematous cholecystitis is relatively rare: in 1971 the cumulative total of cases reported in the world literature was 115. Two cases seen in the period 1967 to 1972 can be added. The features of these two cases, and those described in the literature support the view that emphysematous cholecystitis results from a primary obliterative endarteritis and a secondary proliferation of microorganisms.
