Clinical features, anti-cancer treatments and outcomes of lung cancer patients with combined pulmonary fibrosis and emphysema.

BACKGROUND: Combined pulmonary fibrosis and emphysema (CPFE) patients may be at significantly increased risk of lung cancer compared with either isolated emphysema or pulmonary fibrosis patients. Acute exacerbation (AE) of interstitial lung disease caused by anticancer treatment is the most common lethal complication in Japanese lung cancer patients. Nevertheless, the clinical significance of CPFE compared with isolated idiopathic interstitial pneumonias (IIPs) in patients with lung cancer is not well understood. METHODS: A total of 1536 patients with lung cancer at Nippon Medical School Hospital between March 1998 and October 2011 were retrospectively reviewed. Patients with IIPs were categorized into two groups: (i) CPFE; IIP patients with definite emphysema and (ii) non-CPFE; isolated IIP patients without definite emphysema. The clinical features, anti-cancer treatments and outcomes of the CPFE group were compared with those of the non-CPFE group. RESULTS: CPFE and isolated IIPs were identified in 88 (5.7%) and 63 (4.1%) patients respectively, with lung cancer. AE associated with initial treatment occurred in 22 (25.0%) patients in the CPFE group and in 8 (12.7%) patients in the non-CPFE group, irrespective of treatment modality. Median overall survival (OS) of the CPFE group was 23.7 months and that of the non-CPFE group was 20.3 months (P=0.627). Chemotherapy was performed in a total of 83 patients. AE associated with chemotherapy for advanced lung cancer occurred in 6 (13.6%) patients in the CPFE group and 5 (12.8%) patients in the non-CPFE group. Median OS of the CPFE group was 14.9 months and that of the non-CPFE group was 21.6 months (P=0.679). CONCLUSION: CPFE was not an independent risk factor for AE and was not an independent prognosis factor in lung cancer patients with IIPs. Therefore, great care must be exercised with CPFE as well as IIP patients when performing anticancer treatment for patients with lung cancer.

Environmental influence on the measurement of exhaled nitric oxide concentration in school children: special reference to methodology.

INTRODUCTION: Measuring exhaled nitric oxide (eNO) is a noninvasive and useful method for evaluating the correlation between airway inflammation and air pollution. The method is being used in studies; however, the effects of polluted air on eNO values are poorly understood. If polluted air significantly affects eNO concentrations, then it would be hard to evaluate the concentration of eNO, particularly in epidemiological measurements to detect the effects of airway inflammation, such as that in bronchial asthma. Thus, we hypothesized that short-term exposure to air pollution affects eNO values. PURPOSE: To study the effects of environmental nitrogen oxides on the measurement of eNO concentration. SUBJECTS AND METHODS: A total of 19 school children who lived on a large street with heavy traffic with random allocation were studied. Subjects with bronchial asthma were identified with a questionnaire. Suspended particulate matter. including particulate matter with an aerodynamic diameter < or =2.5 microm (PM(2.5)), optical black carbon, nitric oxide (NO), nitric dioxide (NO(2)), and nitrogen oxides (NO(X)), were measured at a fixed place along the street every hour for 11 consecutive days. The concentrations of NO and NO(2) for each subject were measured by an individual 2-pyenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl sampler, and the concentration of eNO was measured with the off-line method. RESULTS: Of 19 subjects, 3 were found to have bronchial asthma. The level of each pollutant for 11 days peaked during the mornings (6;9 a.m.) and evenings (6;9 p.m.) due to traffic jams; average eNO values in healthy subjects and those with asthma were 27.1 +/- 9.7 and 57.7 +/- 18.6 ppb (p=0.098), respectively. It was found that the eNO value remained high when the mean values of various pollutants remained high for 8 hours before the measurements. It was estimated that the mean eNO values increased by 1.08 ppb (95% CI: 0.72;1.45) when the mean NO(X) value for the previous 8 hours reached approximately 10 ppb. CONCLUSION: We conclude that short-term exposure to polluted air of at least 8 hours before measurement affects eNO values. Therefore, caution should be exercised when measuring eNO value in epidemiological studies.