Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Language
Publication year range
1.
Anal Sci ; 40(1): 213-217, 2024 Jan.
Article in English | MEDLINE | ID: mdl-37831313

ABSTRACT

In the present study, by heating a quartz glass substrate having the dry residue of a 10 µL droplet of a solution of HAuCl4 and a counter substrate facing to the dry residue from room temperature to one hundred and several tens of degrees Celsius in 20 min in air, highly dense gold nanoparticles were produced on the counter substrate. A gold nanoparticle substrate produced by this simple method was utilized as a substrate for surface-enhanced Raman scattering analysis.

3.
Biol Psychiatry ; 80(8): 636-42, 2016 10 15.
Article in English | MEDLINE | ID: mdl-26876947

ABSTRACT

BACKGROUND: Clozapine-induced agranulocytosis (CIA)/clozapine-induced granulocytopenia (CIG) (CIAG) is a life-threatening event for schizophrenic subjects treated with clozapine. METHODS: To examine the genetic factor for CIAG, a genome-wide pharmacogenomic analysis was conducted using 50 subjects with CIAG and 2905 control subjects. RESULTS: We identified a significant association in the human leukocyte antigen (HLA) region (rs1800625, p = 3.46 × 10(-9), odds ratio [OR] = 3.8); therefore, subsequent HLA typing was performed. We detected a significant association of HLA-B*59:01 with CIAG (p = 3.81 × 10(-8), OR = 10.7) and confirmed this association by comparing with an independent clozapine-tolerant control group (n = 380, p = 2.97 × 10(-5), OR = 6.3). As we observed that the OR of CIA (OR: 9.3~15.8) was approximately double that in CIG (OR: 4.4~7.4), we hypothesized that the CIG subjects were a mixed population of those who potentially would develop CIA and those who would not develop CIA (non-CIA). This hypothesis allowed the proportion of the CIG who were non-CIA to be calculated, enabling us to estimate the positive predictive value of the nonrisk allele on non-CIA in CIG subjects. Assuming this model, we estimated that 1) ~50% of CIG subjects would be non-CIA; and 2) ~60% of the CIG subjects without the risk allele would be non-CIA and therefore not expected to develop CIA. CONCLUSIONS: Our results suggest that HLA-B*59:01 is a risk factor for CIAG in the Japanese population. Furthermore, if our model is true, the results suggest that rechallenging certain CIG subjects with clozapine may not be always contraindicated.


Subject(s)
Agranulocytosis/chemically induced , Agranulocytosis/genetics , Clozapine/adverse effects , HLA-B Antigens/genetics , Pharmacogenomic Testing , Adult , Alleles , Asian People/genetics , Case-Control Studies , Female , Genetic Predisposition to Disease/genetics , Genotype , Histocompatibility Testing , Humans , Male , Risk Factors , Sensitivity and Specificity , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...