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2.
Agents Actions ; 27(3-4): 285-6, 1989 Jun.
Article in English | MEDLINE | ID: mdl-2801312

ABSTRACT

The present study was undertaken to investigate the expression of membrane IL-1 (mIL-1) in mouse macrophages. Membrane IL-1 activity was measured on paraformaldehyde fixed peritoneal macrophages using EL4 6.1 lymphocyte cell line. Acid washing prior to fixation did not remove the mIL-1 activity, indicating that mIL-1 is an integral part of the membrane. Adherence to tissue culture plastic plates was found to be a potent inducer of mIL-1 activity in both resident and C. parvum activated macrophages. Dexamethasone reduced mIL-1 activity induced in vivo by C. parvum and also that induced by adherence in vitro.


Subject(s)
Interleukin-1/metabolism , Macrophages/metabolism , Animals , Cell Adhesion , Cell Membrane/analysis , Cell Membrane/drug effects , Cell Membrane/metabolism , Dexamethasone/pharmacology , Macrophages/drug effects , Mice
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