Subject(s)
Antirheumatic Agents/therapeutic use , Autoantibodies/blood , Rituximab/therapeutic use , Scleroderma, Diffuse/drug therapy , Scleroderma, Diffuse/immunology , Antibodies, Antinuclear/blood , Antibodies, Antinuclear/immunology , Autoantibodies/immunology , Biomarkers/blood , DNA Topoisomerases, Type I/blood , DNA Topoisomerases, Type I/immunology , Dose-Response Relationship, Drug , Humans , Immunologic Surveillance , Scleroderma, Diffuse/blood , Sensitivity and Specificity , Time Factors , Treatment OutcomeSubject(s)
Antibodies, Monoclonal, Murine-Derived/administration & dosage , Pulmonary Fibrosis/drug therapy , Scleroderma, Systemic/diagnosis , Scleroderma, Systemic/drug therapy , Antibodies, Monoclonal, Murine-Derived/adverse effects , Disease Progression , Dose-Response Relationship, Drug , Drug Administration Schedule , Female , Follow-Up Studies , Humans , Male , Pulmonary Fibrosis/etiology , Risk Assessment , Rituximab , Scleroderma, Systemic/complications , Severity of Illness Index , Treatment OutcomeABSTRACT
OBJECTIVES: As interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients is associated with increased mortality due to loss of diffusion capacity and pulmonary hypertension, regular screening for structural abnormalities of the lung is advised. In addition to standard radiological examination with computed x-ray tomography, ultrasound of the lung could allow non-invasive and radiation-free structural monitoring of the lung. The objective of this study was to test the frequency of abnormalities in lung sonography in patients with RA who did not have clinical signs or symptoms of lung disease. METHODS: In a prospective study of 64 consecutive patients with rheumatoid arthritis and 40 healthy volunteers, we screened the pleura and the pulmonary parenchyma for sonographic abnormalities. All RA patients underwent high resolution computer tomography of the lung. RESULTS: 28% of RA patients showed pleural nodules or B-line phenomena. In these patients, CT scans showed signs of incipient interstitial lung disease. Lung sonography showed sporadic abnormalities in 7% of the healthy controls. CONCLUSIONS: Transthoracic ultrasound of the lung is an inexpensive and safe tool to screen patients with RA for incipient pulmonary structural changes.
Subject(s)
Arthritis, Rheumatoid/complications , Lung Diseases, Interstitial , Lung/pathology , Pleura/pathology , Ultrasonography/methods , Aged , Asymptomatic Diseases/epidemiology , Austria/epidemiology , Comparative Effectiveness Research , Female , Humans , Lung Diseases, Interstitial/diagnosis , Lung Diseases, Interstitial/epidemiology , Lung Diseases, Interstitial/physiopathology , Male , Mass Screening/methods , Mass Screening/statistics & numerical data , Middle Aged , Prevalence , Prospective Studies , Tomography, X-Ray Computed/methodsABSTRACT
In systemic sclerosis patients, interstitial lung disease and pulmonary hypertension are highly associated with mortality. The time point of detecting manifestations like pulmonary hypertension and interstitial lung disease (ILD) is of vital importance. High-resolution computed tomography (HRCT) to date is the gold standard to diagnose ILD. In addition, an ultrasound of the lung is suggested as a noninvasive and radiation-free method of structural monitoring of the lung. We tested the reliability of lung sonography for the assessment of patients with systemic sclerosis. In a pilot study involving 25 patients with systemic sclerosis and 40 healthy volunteers, we screened the pleura and the pulmonary parenchyma for sonographic abnormalities. The occurrence of B lines, comet tail phenomena, and pleural irregularities was scored. All systemic sclerosis (SSc) patients were subjected to computed x-ray tomography of the chest. Forty-four percent of SSc patients showed B line phenomena and pleural thickening. The diagnosis of ILD in these patients was confirmed by HRCT scan. B line phenomena and pleural irregularities were significantly more common in SSc patients. Patients with ILD had higher pleural scores and comet scores when compared to systemic sclerosis patients without radiographic ILD. If our results are confirmed in larger studies, transthoracic ultrasound of the lung might turn out to be a suitable method for screening patients with systemic sclerosis for incipient pulmonary structural changes.
