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1.
Lophyrotomin, a new toxic octapeptide from the larvae of sawfly, Lophyrotoma interrupta.
Oelrichs, P B; Vallely, P J; Macleod, J K; Cable, J; Kiely, D E; Summons, R E.
Lloydia ; 40(2): 209-14, 1977.
Article in English | MEDLINE | ID: mdl-17805

ABSTRACT

Lophyrotomin, a new toxic octapeptide, has been isolated from sawfly (Lophyrotoma interrupta) larvae using solvent extraction, dialysis, adsorption on polyamide, ion exchange chromatography on DEAE cellulose and silica gel G chromatography. On the basis of evidence from chemical methods, pmr and mass spectrometry, a partial structure is proposed. Lophyrotomin has an approximate intraperitoneal LD50 of 2 mg/kg for mice.


Subject(s)
Diptera/embryology , Oligopeptides/toxicity , Toxins, Biological/isolation & purification , Amino Acids/analysis , Animals , Hydrogen-Ion Concentration , Larva/analysis , Lethal Dose 50 , Oligopeptides/isolation & purification , Solubility , Species Specificity
2.
A chemical model for the cyclization step in the biosynthesis of L-myo-inositol 1-phosphate.
Kiely, D E; Sherman, W R.
J Am Chem Soc ; 97(23): 6810-4, 1975 Nov 12.
Article in English | MEDLINE | ID: mdl-1184880

Subject(s)
Inositol/analogs & derivatives , Inositol/biosynthesis , Inositol Phosphates , Models, Chemical , Myo-Inositol-1-Phosphate Synthase , Sugar Phosphates/biosynthesis
3.
A synthesis of (plus or minus)-myo-inositol 1-phosphate.
Kiely, D E; Abruscato, G J; Baburao, V.
Carbohydr Res ; 34(2): 307-13, 1974 Jun.
Article in English | MEDLINE | ID: mdl-4366895

Subject(s)
Phosphatidylinositols/chemical synthesis , Chromatography, Gas , Chromatography, Ion Exchange , Crystallization , Mass Spectrometry
4.
Chemical studies relevant to the biosynthesis of inositols.
Kiely, D E; Fletcher, H G.
Ann N Y Acad Sci ; 165(2): 559-63, 1969 Oct 17.
Article in English | MEDLINE | ID: mdl-5259613

Subject(s)
Inositol/chemical synthesis , Glucose
5.
Cyclization of D-xylo-hexos-5-ulose, a chemical synthesis of scyllo- and myo-inositols from D-glucose.
Kiely, D E; Fletcher, H G.
J Org Chem ; 34(5): 1386-90, 1969 May.
Article in English | MEDLINE | ID: mdl-5786171

Subject(s)
Glucose , Hexoses , Inositol/chemical synthesis , Chemical Phenomena , Chemistry
6.
Chemical synthesis of D-xylo-hexos-5-ulose 6-phosphate, a putative intermediate in the biosynthesis of myo-inositol.
Kiely, D E; Fletcher, H G.
J Org Chem ; 33(10): 3723-7, 1968 Oct.
Article in English | MEDLINE | ID: mdl-5743775

Subject(s)
Hexosephosphates/chemical synthesis , Inositol/biosynthesis
7.
Catalpa glycosides. IV. The stereochemistry of catalposide.
Bobbitt, J M; Kiely, D E; Lam, A Y; Snyder, E I.
J Org Chem ; 32(5): 1459-61, 1967 May.
Article in English | MEDLINE | ID: mdl-6041429

Subject(s)
Glycosides , Magnetic Resonance Spectroscopy
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