ABSTRACT
In a control group of anaesthetized dogs, a reduction in the number and speed of peristaltic movements of the ureter was observed during anaphylactic and dye shock. In the second, experimental, group of dogs the effect during fully-developed shock of an intravenous injection of adrenaline at the maximum active dose on the ureter dynamics was investigated. It was found that adrenaline increased the number and, to an even greater extent, the speed of peristaltic movements over a period of a few minutes' duration during which the arterial pressure remained high. It seems that adrenaline first and foremost facilitates the conduction of peristaltic stimuli in the ureter.
Subject(s)
Epinephrine/therapeutic use , Muscle Contraction , Shock/physiopathology , Ureter/physiopathology , Anaphylaxis/physiopathology , Animals , Disease Models, Animal , Dogs , Muscle Contraction/drug effectsABSTRACT
The investigations were undertaken for tracing changes occurring in exercise-related metabolites and pressure of respiratory blood gases, for observing in this way the development of post-exercise restitution in animals with pharmacological blockade of the carotid sinuses. The experiments were done on control and experimental rats with sinus blockade produced by means of 1.0 microliter lignocaine injected into the area of the sinuses. The animals were subjected to a workload performing a work of 188.6 J/m/sec at a power of 0.104 of W/m/sec. The measurements included the heart rate, the amplitude of respiration rates, blood levels of glucose, lactate, pyruvate and LDH activity. In the arterial blood and venous blood the values of pO2 and pCO2, H+ concentration and base reserve and the index of O2 utilization were determined. Differences were found between the control group and the group with sinus receptor blockade with an earlier return of the determined values to their initial state in the experimental group. The increase of the O2 utilization index in the experimental animals paralleled the lactate fall and LDH rise, and H+ concentration was unchanged. These changes show that carotid sinuses receptors cooperate with the mechanisms regulating postexercise restitution.
Subject(s)
Autonomic Nerve Block , Carotid Sinus/innervation , Efficiency , Lidocaine/pharmacology , Physical Exertion , Pressoreceptors/drug effects , Animals , Blood Glucose/analysis , Carbon Dioxide/blood , Heart Rate/drug effects , L-Lactate Dehydrogenase/blood , Lactates/blood , Male , Oxygen/blood , Pyruvates/blood , Rats , Respiration/drug effectsABSTRACT
The effect of electrophoretic lignocaine blockade in the region of the carotid sinuses on changes in the intensity of spontaneous and water diuresis was investigated on anaesthetized dogs. After the blockade a reduction in spontaneous diuresis was observed and a marked and statistically significant restriction of water diuresis was noted as compared with the control experiments. The reduction in diuresis after the blockade was of a brief duration and did not appear to be related to changes in the intensity of the filtration through the kidneys, which was only slightly lower, but to changes in reabsorption. In all probability, the carotid blockade is connected with a dominance of hormonal effects by elimination of the effect of the nervi vagi, osmoreceptors of the carotid arteries and in particular the chemoreceptors of the carotid body.
Subject(s)
Carotid Sinus/drug effects , Diuresis , Lidocaine/pharmacology , Animals , Carotid Sinus/innervation , Chemoreceptor Cells/drug effects , Chemoreceptor Cells/physiology , Dogs , Female , Kidney/innervation , Male , Neural Pathways , Vagus Nerve/physiologyABSTRACT
In experiments performed on anaesthetized dogs the effects of dye shock and peptone shock on changes in serum osmolality, haematocrit value, amino acid level in serum and erythrocytes, and serum total protein and protein fraction levels were determined. In further experid (0.1 mg/kg). It was found that Arfonad exerts an inhibitory effect on the shock-induced reduction in the serum osmolality, plasma volume and on the albumin level.
Subject(s)
Blood Proteins/analysis , Hemodynamics/drug effects , Nitrogen/blood , Shock, Hemorrhagic/blood , Trimethaphan/pharmacology , Animals , Coloring Agents/adverse effects , Dogs , Female , Hematocrit , Histamine Release/drug effects , Injections, Intravenous , Male , Peptones/adverse effects , Serum Albumin/analysis , Shock, Hemorrhagic/chemically induced , Trimethaphan/administration & dosageABSTRACT
The effects of peptone shock on changes in the arterial blood pressure, respiration and urine excretion induced by bladder distension were investigated in 8 anaesthetized female dogs. It was found that during shock when the arterial blood pressure reaches its lowest value no effect can be induced. Later on, when the arterial blood pressure rose to intermediate values the intensity of the reflex effects were proportional to the value of arterial blood pressure. After shock when the arterial pressure was normal again the reflex effects were slightly less intenisve than the control ones obtained before shock, and they were dependent on biochemical changes affecting the nervous centres participating in the reflex.
