1.
Nucleosides Nucleotides Nucleic Acids
; 23(8-9): 1201-4, 2004 Oct.
Article
in English
| MEDLINE
| ID: mdl-15571231
ABSTRACT
Urate is largely excluded from the brain under non-inflammatory conditions (concentration gradient serum:CSF about 10:1), but increases markedly in Guillain-Barré Syndrome and bacterial meningitis. The oxidation product allantoin is normally not passively distributed between blood and cerebrospinal fluid (gradient 3:1) and increases 5-fold in CSF of patients with meningitis. Patients with multiple sclerosis had normal levels of urate and allantoin in blood and CSF.