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3.
Article in Polish | MEDLINE | ID: mdl-8771842

ABSTRACT

Kidneys of the rats kept on a diet containing electroenergetical ashes were examined histochemically. An increase in activity of enzymes in cells of kidney canaliculi in animals which were the longest subject to experiment, were observed.


Subject(s)
Dust , Kidney/pathology , Metals/administration & dosage , Administration, Oral , Animals , Diet , Female , Incineration , Kidney/enzymology , L-Lactate Dehydrogenase/metabolism , Rats , Succinate Dehydrogenase/metabolism
5.
Article in Polish | MEDLINE | ID: mdl-1365798

ABSTRACT

Normal metabolism, regulation of stimulation and checking of electrolyte secretion in the gastric juice depend on the way of feeding and its nutritional ingredients. Feeding experimental animals with fodder containing power plant ashes or loess dusts causes a change in the gastric juice reaction, thus resulting in a different assimilation of elements contained in the fodder. There was shown an increase of some elements content (Mg, Na, Cu, Fe), a decrease in the content of some others (Pb,Zn) in the gastric juice and a positive tendency for blocking by calcium ions of heavy metals contained in the fodder by the mucous membrane of the stomach.


Subject(s)
Dust/adverse effects , Electrolytes/analysis , Food Contamination, Radioactive , Gastric Juice/chemistry , Power Plants , Animals , Gastric Juice/metabolism , Gastric Mucosa/metabolism , Male , Metals/pharmacokinetics , Mucous Membrane/metabolism , Rats , Rats, Wistar
7.
Rocz Panstw Zakl Hig ; 42(2): 179-83, 1991.
Article in Polish | MEDLINE | ID: mdl-1803446

ABSTRACT

The examination studied behaviour of rats fed on natritive material containing soil dust or electroenergetic ashes. Food containing the dust or ashes was administered to animals in the amount of 30 g a day for 26 weeks. Body weight was controlled in all animals and their motor activity, motor coordination and cognitive activity were examined. It has been settled that rats fed an food with the soil dust supplement showed higher motor activity and acquired greater motor coordination than animals fed either on food with the electroenergetic ashes supplement or on conventional food. During the first weeks of experiment, cognitive activity was getting lower in animals in both experimental groups and control group, and then only in the group of animals fed on food with the soil dust supplement.


Subject(s)
Behavior, Animal , Cognition/physiology , Feeding Behavior , Models, Biological , Motor Activity/physiology , Animal Feed , Animals , Carbon , Coal Ash , Dust , Female , Food, Fortified , Particulate Matter , Rats , Rats, Inbred Strains , Soil , Time Factors
8.
Article in Polish | MEDLINE | ID: mdl-1364992

ABSTRACT

White male [correction of female] rats were given Dexamethasone in a single dose 0.35 mg/24 hrs. Group I was given the drug once, group II--received it for 2 days, and group III--for 7 days. 24 hrs after the medicine had been given the mucous membrane of the stomach corpus was collected for examinations. There were performed: H+E staining, PAS reaction and histochemical reaction to the activity of ATP-ase, acid phosphatase and alkaline phosphatase. The results obtained were compared with those obtained in a group of control animals which were given distilled water. The administration of Dexamethasone did not affect significantly the activity of the examined hydrolases, however, it damaged the mucous barrier of the stomach, specially in the animals after 7 days of application of the drug.


Subject(s)
Dexamethasone/pharmacology , Gastric Mucosa/drug effects , Acid Phosphatase/metabolism , Adenosine Triphosphatases/metabolism , Alkaline Phosphatase/metabolism , Animals , Gastric Mucosa/enzymology , Gastric Mucosa/pathology , Male , Rats , Rats, Wistar
9.
Article in Polish | MEDLINE | ID: mdl-1364993

ABSTRACT

Female rats were given intragastrically, by means of a probe, Vibramycine in suspension, in a dose 4 mg/kg body weight, in different stages of pregnancy. On kidney sections there were performed: H+E staining, PAS reaction, histochemical determination of enzymes activity: alkaline phosphatase, ATP-ase, SDH and LDH. In non-pregnant females receiving the drug there was observed an intensification of alkaline phosphatase activity in brush border of main tubules of the kidney and a slight broadening of the light of the tubules. In pregnant females receiving the drug, most clearly in the second half of pregnancy a slight intensification of the activity of the examined enzymes was observed.


Subject(s)
Doxycycline/pharmacology , Kidney/drug effects , Pregnancy, Animal/metabolism , Adenosine Triphosphatases/metabolism , Alkaline Phosphatase/metabolism , Animals , Female , Kidney/enzymology , Kidney/pathology , L-Lactate Dehydrogenase/metabolism , Pregnancy , Rats , Succinate Dehydrogenase/metabolism
10.
Article in Polish | MEDLINE | ID: mdl-1365003

ABSTRACT

Kidneys of the rats which had been intragastrically administered Dexamethasone (10 mg/kg), were examined. Observations were carried out after a single and twice repeated application of the preparation, as well as after 7 days of everyday administration. It was found, on the basis of histological and histochemical observations (reaction to alkaline phosphatase activity, reaction to acid phosphatase activity, PAS-method staining), that both single and twice administration of Dexamethasone do not cause the damage of the kidney parenchyma, whereas after 7 days of everyday application of the preparation irreversible changes can be observed.


Subject(s)
Dexamethasone/toxicity , Kidney/drug effects , Administration, Oral , Animals , Drug Administration Schedule , Kidney/pathology , Male , Rats , Rats, Wistar
11.
Gegenbaurs Morphol Jahrb ; 136(5): 565-74, 1990.
Article in German | MEDLINE | ID: mdl-2083820

ABSTRACT

The experiment was carried out on white Wistar rats. The rats in the experimental groups received fodder containing power station ashes for various periods of time (from 6 to 18 weeks). During the experiment, the body weight of rats was recorded, the amount of trace elements in the liver was estimated, and morphological tests of the liver were carried out. The results of these experiments indicate that feeding the rats on fodder containing power station ashes causes several percent increase in the body weight and slight differences in accumulation of trace elements. Morphological changes in the liver are connected with the vacuolization of the hepatocytes' cytoplasma and an increase in the amount of phagocytic cells in hepatic sinuses. The intensity of morphological changes was correlated with the time of experiment.


Subject(s)
Industrial Waste/adverse effects , Liver/pathology , Power Plants , Trace Elements/analysis , Animal Feed , Animals , Body Weight , Liver/chemistry , Male , Rats , Rats, Inbred Strains
12.
Article in Polish | MEDLINE | ID: mdl-1670025

ABSTRACT

Investigations refer to the influence of fodder containing soil dust as one of the ingredients on morphology of the liver and the weight of experimental animals. Fodder containing soil dust was given to animals for various periods of time, the longest was 18 weeks. The results indicate that the intensity of morphological changes in the liver depends on the time of giving fodder. The observed changes referred to the vacuolization of hepatocytes, increase in the number of stellate cells Browicz-Kupffer, and apart from that lymphocytic infiltrations occurred locally. The weight of the experimental animals in the initial period (up to 3 weeks) decreased and then came back to normal in the later period, but in some animals it even decreased.


Subject(s)
Dust/adverse effects , Liver/pathology , Soil , Administration, Oral , Animals , Body Weight , Rats , Rats, Wistar
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