[Relation of serum uric acid levels with basic metabolic parameters in patients with metabolic syndrome during insulin-sensitizing therapy].

The aim of our investigation was to study the peculiarities of serum uric acid (UA) levels in patients with metabolic syndrome (MS) during 6 month therapy with metformin (MF), Rosiglitazone (RG) and their combination. 30 patients with MS (10 males, 20 females, mean age - 35,5+/-9,7 years) have been investigated by all parameters of MS and serum UA levels. Investigated group was divided into 3 subgroups of 10 patients: group 1 - patients on RG; group 2 - patients on MF; group 3 - patients on RG + 850-1000 mg of MF. Results of investigation showed that UA serum levels did not decrease significantly. However, the frequency of hyperuricemia decreased significantly. PPG, basal C-peptide, and HOMA-% IR also decreased significantly. Despite percentage reduction of BMI in group 3 (7,6%), decrease of UA and HOMA-IR was significantly higher in group 1 (18,2% and 37.0%, respectively). Correlation analysis showed that decrease of UA significantly correlated with BMI and HOMA-IR in the whole group (r=0.5674, p=0.001; r=0.5437, p=0.002; respectively); in group 1 - with HOMA-IR (r=0.5753, p=0.016); in group 3 - with BMI (r=0.7821, p<0.001). Obtained results showed that UA levels and hyperuricemia cases significantly decreased during insulin sensitizing therapy.

[Biochemical markers of bone metabolism and cortical bone mineral density in young healthy females].

The goal of the study was to investigate biochemical markers of bone metabolism and cortical BMD in young healthy females. 62 young, practically healthy females, 15-35 years of age were involved in this study. Osteoporosis risk factors were assessed by means of the special questionnaire. SOS (speed of sound) was measured in the middle of tibia by ultrasound densitometer Sound Scan Compact (Myriad, Israel). The bone mineral density of 62 young females varied depending on the risk factors such as low body mass, low calcium intake, smoking and unbalanced low calorie diet. Body mass index strongly correlated with the BMD. For effective control and prevention of osteoporosis, it is essential to identify risk-groups among healthy population for follow-up screening and providing adequate measures.