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1.
Brain ; 133(Pt 6): 1747-54, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20413575

ABSTRACT

Olfactory dysfunction is common in subjects with Parkinson's disease. The pathophysiology of such dysfunction, however, remains poorly understood. Neurodegeneration within central regions involved in odour perception may contribute to olfactory dysfunction in Parkinson's disease. Central cholinergic deficits occur in Parkinson's disease and cholinergic neurons innervate regions, such as the limbic archicortex, involved in odour perception. We investigated the relationship between performance on an odour identification task and forebrain cholinergic denervation in Parkinson's disease subjects without dementia. Fifty-eight patients with Parkinson's disease (mean Hoehn and Yahr stage 2.5 + or - 0.5) without dementia (mean Mini-Mental State Examination, 29.0 + or - 1.4) underwent a clinical assessment, [(11)C]methyl-4-piperidinyl propionate acetylcholinesterase brain positron emission tomography and olfactory testing with the University of Pennsylvania Smell Identification Test. The diagnosis of Parkinson's disease was confirmed by [(11)C]dihydrotetrabenazine vesicular monoamine transporter type 2 positron emission tomography. We found that odour identification test scores correlated positively with acetylcholinesterase activity in the hippocampal formation (r = 0.56, P < 0.0001), amygdala (r = 0.50, P < 0.0001) and neocortex (r = 0.46, P = 0.0003). Striatal monoaminergic activity correlated positively with odour identification scores (r = 0.30, P < 0.05). Multiple regression analysis including limbic (hippocampal and amygdala) and neocortical acetylcholinesterase activity as well as striatal monoaminergic activity, using odour identification scores as the dependent variable, demonstrated a significant regressor effect for limbic acetylcholinesterase activity (F = 10.1, P < 0.0001), borderline for striatal monoaminergic activity (F = 1.6, P = 0.13), but not significant for cortical acetylcholinesterase activity (F = 0.3, P = 0.75). Odour identification scores correlated positively with scores on cognitive measures of episodic verbal learning (r = 0.30, P < 0.05). These findings indicate that cholinergic denervation of the limbic archicortex is a more robust determinant of hyposmia than nigrostriatal dopaminergic denervation in subjects with moderately severe Parkinson's disease. Greater deficits in odour identification may identify patients with Parkinson's disease at risk for clinically significant cognitive impairment.


Subject(s)
Brain/metabolism , Cognition Disorders/metabolism , Olfactory Perception , Parkinson Disease/metabolism , Perceptual Disorders/metabolism , Acetylcholinesterase/metabolism , Aged , Aged, 80 and over , Biogenic Monoamines/metabolism , Brain/diagnostic imaging , Brain/enzymology , Cognition Disorders/diagnostic imaging , Cognition Disorders/enzymology , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Neuropsychological Tests , Parkinson Disease/diagnostic imaging , Parkinson Disease/enzymology , Pattern Recognition, Physiological , Perceptual Disorders/diagnostic imaging , Perceptual Disorders/enzymology , Physical Stimulation , Positron-Emission Tomography , Vesicular Monoamine Transport Proteins/metabolism
2.
J Cereb Blood Flow Metab ; 28(3): 441-4, 2008 Mar.
Article in English | MEDLINE | ID: mdl-18073772

ABSTRACT

Postmortem data indicate loss of serotoninergic neurons in Parkinson's disease (PD). We used the serotonin transporter (SERT) radioligand 3-amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitril (DASB) and positron emission tomography to examine SERT distribution and changes in early PD subjects. We studied five PD subjects (H&Y 1 to 2.5) and eight normal controls. There is reduced SERT binding in PD. The magnitude of DASB binding reductions was greater in the forebrain than in the brainstem regions. There was no asymmetry of diminished SERT binding. DASB binding in the medulla was relatively spared, inconsistent with the description of early prominent pathologic study in these caudal brainstem nuclei.


Subject(s)
Brain Stem/chemistry , Parkinson Disease/metabolism , Serotonin Plasma Membrane Transport Proteins/analysis , Adult , Aged , Brain Chemistry , Brain Stem/pathology , Case-Control Studies , Female , Humans , Male , Medulla Oblongata/chemistry , Medulla Oblongata/pathology , Middle Aged , Nerve Tissue Proteins , Parkinson Disease/pathology , Positron-Emission Tomography , Prosencephalon/chemistry , Prosencephalon/pathology , Protein Binding/physiology , Radioligand Assay , Serotonin Plasma Membrane Transport Proteins/metabolism , Time Factors
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