ABSTRACT
Our study shows that treatment recommendations provided through social media are based on evidence of variable quality. However, on Youtube®, there was no significant difference between viewership numbers between physicians and nonphysicians. Therefore, Dermatologists with expertise in alopecia should consider utilizing social media to promote evidence-based treatment options for all alopecia subtypes.
Subject(s)
Social Media , Alopecia/therapy , Cross-Sectional Studies , Humans , Video RecordingABSTRACT
This case illustrates a presentation with dystrophic calcinosis cutis recalcitrant to several treatment modalities. Treatment with extracorporeal shockwave lithotripsy was initiated with near complete resolution of calcium deposits.
Subject(s)
Calcinosis/pathology , Calcinosis/therapy , Lithotripsy , Skin Diseases/pathology , Skin Diseases/therapy , Aged , Female , Humans , Treatment OutcomeSubject(s)
Keratosis, Actinic , Cryotherapy , Humans , Keratosis, Actinic/drug therapy , Pain/etiology , Treatment OutcomeABSTRACT
PURPOSE: Statistical models using preoperative Prostate-Specific Antigen, Gleason primary grade or score of the biopsy specimen, and clinical stage have been developed to predict those patients with clinically localized prostate cancer at low risk for lymph node metastasis. It has been recommended that these patients do not require pelvic lymph node dissections. Four such models were evaluated to assess their accuracy in identifying this subgroup of patients. METHODS AND MATERIALS: We reviewed the records of 214 patients with clinically localized prostate cancer who underwent pelvic lymph node dissections. Data from these patients were entered into the four models. RESULTS: Lymph node metastasis was detected in 14% of patients. The results showed the following for each of the proposed models respectively: 78, 50, 76, and 42% of the patients were identified as low risk and, hence, would be spared pelvic lymph node dissections. The false negative rates are 13 (7.8%), 5 (4.6%), 14 (8.6%), and 1 (1.1%). Sensitivities are 56.7, 83.3, 53.3, and 96.7%. CONCLUSIONS: While the pelvic lymph node dissection is the most accurate method of detecting occult nodal metastasis, statistical models can identify a cohort of low risk patients that may be spared lymphadenectomy.
Subject(s)
Lymphatic Metastasis , Prostatic Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Evaluation Studies as Topic , Humans , Lymph Node Excision , Lymph Nodes/pathology , Male , Middle Aged , Models, Statistical , Neoplasm Staging , Predictive Value of Tests , Prostate-Specific Antigen/blood , Prostatectomy , Prostatic Neoplasms/blood , Prostatic Neoplasms/surgery , Risk FactorsABSTRACT
Toxic strains of the finely filamentous, velvety, dark-olive green to black algal organism, Microcolus Lyngbyaceus, (formerly Lyngbya majuscula Gomont, or "lyngbya") have been recognized as etiologic agent of "stinging seaweed" dermatitis (one of several forms of "swimmer's itch") in Hawaii since the late 1950s as reviewed. Lymphadenopathy, pustular folliculitus, and local infections have been reported in some persons.
Subject(s)
Dermatitis, Contact/etiology , Seaweed , Vibrio/isolation & purification , Water Microbiology , Cyanobacteria , Dermatitis, Contact/microbiology , Disease Outbreaks , Humans , Lyngbya Toxins/adverse effectsABSTRACT
There were 65 patients with squamous cell carcinoma of the penis followed for a minimum of 5 years. Patients with stage I disease uniformly survived with local treatment only. Of the patients with stages II and III carcinoma of the penis 88 and 66 per cent, respectively, were free of disease if lymphadenectomy was performed shortly following treatment of the primary lesion, compared to only 38 and 0 per cent, respectively, if the primary lesion was treated locally and no lymphadenectomy was performed. These data support the concept that lymphadenectomy should be an integral part of the primary treatment in patients with stages II and III penile cancer.
Subject(s)
Carcinoma, Squamous Cell/surgery , Lymph Nodes/surgery , Penile Neoplasms/surgery , Adult , Aged , Carcinoma, Squamous Cell/pathology , Female , Humans , Lymph Nodes/pathology , Male , Middle Aged , Penile Neoplasms/pathologyABSTRACT
In previous studies using dogs whose renal function was rendered asymmetric by unilateral infarction or partial ureteral obstruction, the efficacy of technetium-99m diethylenetriamine pentaacetic acid and dimercaptosuccinic acid in the measurement of differential renal function was demonstrated. The present study was undertaken to determine if technetium-99m glucoheptonate could also be used to quantitate differential renal function in these conditions. Five dogs with partial ureteral obstruction, 4 with segmental infarction and 2 with ipsilateral combination of both were studied. Seven to 10 days following these interventions the animals were given a bolus injection of 10 mCi Tc-99m glucoheptonate. This was acquired in the posterior projection on a minicomputer at 2 seconds/frame for 3 minutes. Static images were obtained anteriorly and posteriorly between 3 and 5 hours postinjection. The following day iothalamate and creatinine clearances were measured by ureteral catheterization. There was good correlation between differential function calculated from the 1 to 3 minute portion of the bolus study and that determined by the ureteral catheter studies, r greater than 0.99. Correlations based on the static images were less satisfactory due to pelvic retention in the obstructed animals, r = 0.73. We conclude that technetium-99m glucoheptonate may be used to determine differential renal function.
