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1.
Nat Commun ; 6: 6566, 2015 Mar 18.
Article in English | MEDLINE | ID: mdl-25782446

ABSTRACT

Hard and soft structural composites found in biology provide inspiration for the design of advanced synthetic materials. Many examples of bio-inspired hard materials can be found in the literature; far less attention has been devoted to soft systems. Here we introduce deterministic routes to low-modulus thin film materials with stress/strain responses that can be tailored precisely to match the non-linear properties of biological tissues, with application opportunities that range from soft biomedical devices to constructs for tissue engineering. The approach combines a low-modulus matrix with an open, stretchable network as a structural reinforcement that can yield classes of composites with a wide range of desired mechanical responses, including anisotropic, spatially heterogeneous, hierarchical and self-similar designs. Demonstrative application examples in thin, skin-mounted electrophysiological sensors with mechanics precisely matched to the human epidermis and in soft, hydrogel-based vehicles for triggered drug release suggest their broad potential uses in biomedical devices.


Subject(s)
Biomimetic Materials , Materials Testing , Biocompatible Materials/chemistry , Biomimetics , Drug Delivery Systems , Elastic Modulus , Electronics , Electrophysiology , Epidermis/metabolism , Finite Element Analysis , Hardness , Humans , Hydrogels/chemistry , Imides/chemistry , Skin , Stress, Mechanical , Tensile Strength , Tissue Engineering/methods
2.
Nat Commun ; 5: 4779, 2014 Sep 03.
Article in English | MEDLINE | ID: mdl-25182939

ABSTRACT

Research in stretchable electronics involves fundamental scientific topics relevant to applications with importance in human healthcare. Despite significant progress in active components, routes to mechanically robust construction are lacking. Here, we introduce materials and composite designs for thin, breathable, soft electronics that can adhere strongly to the skin, with the ability to be applied and removed hundreds of times without damaging the devices or the skin, even in regions with substantial topography and coverage of hair. The approach combines thin, ultralow modulus, cellular silicone materials with elastic, strain-limiting fabrics, to yield a compliant but rugged platform for stretchable electronics. Theoretical and experimental studies highlight the mechanics of adhesion and elastic deformation. Demonstrations include cutaneous optical, electrical and radio frequency sensors for measuring hydration state, electrophysiological activity, pulse and cerebral oximetry. Multipoint monitoring of a subject in an advanced driving simulator provides a practical example.


Subject(s)
Blood Gas Monitoring, Transcutaneous/instrumentation , Electronics/instrumentation , Equipment Design , Monitoring, Physiologic/instrumentation , Oximetry/instrumentation , Blood Gas Monitoring, Transcutaneous/methods , Brain/physiology , Elasticity , Electrophysiological Phenomena , Humans , Monitoring, Physiologic/methods , Oximetry/methods , Silicones/chemistry , Skin/metabolism
3.
Nat Commun ; 5: 3329, 2014 Feb 25.
Article in English | MEDLINE | ID: mdl-24569383

ABSTRACT

Means for high-density multiparametric physiological mapping and stimulation are critically important in both basic and clinical cardiology. Current conformal electronic systems are essentially 2D sheets, which cannot cover the full epicardial surface or maintain reliable contact for chronic use without sutures or adhesives. Here we create 3D elastic membranes shaped precisely to match the epicardium of the heart via the use of 3D printing, as a platform for deformable arrays of multifunctional sensors, electronic and optoelectronic components. Such integumentary devices completely envelop the heart, in a form-fitting manner, and possess inherent elasticity, providing a mechanically stable biotic/abiotic interface during normal cardiac cycles. Component examples range from actuators for electrical, thermal and optical stimulation, to sensors for pH, temperature and mechanical strain. The semiconductor materials include silicon, gallium arsenide and gallium nitride, co-integrated with metals, metal oxides and polymers, to provide these and other operational capabilities. Ex vivo physiological experiments demonstrate various functions and methodological possibilities for cardiac research and therapy.


Subject(s)
Algorithms , Heart/physiology , Membranes, Artificial , Models, Cardiovascular , Pericardium/physiology , Animals , Elastomers/chemistry , Electrocardiography/instrumentation , Electrocardiography/methods , Electrodes , Electrophysiologic Techniques, Cardiac/instrumentation , Electrophysiologic Techniques, Cardiac/methods , Epicardial Mapping/instrumentation , Epicardial Mapping/methods , Heart/anatomy & histology , Heart Conduction System/physiology , Hydrogen-Ion Concentration , Imaging, Three-Dimensional , In Vitro Techniques , Pericardium/anatomy & histology , Rabbits , Reproducibility of Results , Semiconductors , Silicones/chemistry , Temperature
4.
Environ Technol ; 30(4): 329-36, 2009 Apr 01.
Article in English | MEDLINE | ID: mdl-19492544

ABSTRACT

A membrane-electrode assembly (MEA) was applied to a microbial fuel cell (MFC) type biological oxygen demand (BOD) sensor and the performance of the sensor was assessed. To establish the optimal conditions for MEA fabrication, platinum-catalysed carbon cloth cathodic electrodes were assembled with cation exchange membranes under various temperatures and pressures. By analysing coulombs from the MFCs, it could be determined that the optimal hot-pressing conditions were 120 degrees C and 150 kg cm(-2) for 30 s. When the MEA fabricated under optimal conditions and an air cathode were utilized for the construction of the MFC type BOD sensor, coulombs increased to 4.65 C from 0.52 C and power increased to 69,080 mW m(-3) from 880 mW m(-3) (at a BOD concentration of 200 mg L(-1)), respectively, compared with the conventional MFC lacking a MEA. The increased power improved the performance of the MFC type BOD sensor: sensitivity increased from 1.2 x 10(-3) to 1.8 x 10(-2) C per mg L(-1) of BOD, with good linearity (r2 = 0.97) and over 97% repeatability. We conclude that the MEA can be successfully applied to MFCs to make them highly sensitive BOD sensors.


Subject(s)
Biosensing Techniques/methods , Membranes, Artificial , Oxygen Consumption , Air , Bacteria/metabolism , Electrodes , Equipment Design , Linear Models , Platinum/chemistry , Reproducibility of Results , Sensitivity and Specificity , Sewage/chemistry , Sewage/microbiology , Shewanella putrefaciens/metabolism
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