Navigating the Future of 3D Laparoscopic Liver Surgeries: Visualization of Internal Anatomy on Laparoscopic Images With Augmented Reality.

INTRODUCTION: Liver tumor resection requires precise localization of tumors and blood vessels. Despite advancements in 3-dimensional (3D) visualization for laparoscopic surgeries, challenges persist. We developed and evaluated an augmented reality (AR) system that overlays preoperative 3D models onto laparoscopic images, offering crucial support for 3D visualization during laparoscopic liver surgeries. METHODS: Anatomic liver structures from preoperative computed tomography scans were segmented using open-source software including 3D Slicer and Maya 2022 for 3D model editing. A registration system was created with 3D visualization software utilizing a stereo registration input system to overlay the virtual liver onto laparoscopic images during surgical procedures. A controller was customized using a modified keyboard to facilitate manual alignment of the virtual liver with the laparoscopic image. The AR system was evaluated by 3 experienced surgeons who performed manual registration for a total of 27 images from 7 clinical cases. The evaluation criteria included registration time; measured in minutes, and accuracy; measured using the Dice similarity coefficient. RESULTS: The overall mean registration time was 2.4±1.7 minutes (range: 0.3 to 9.5 min), and the overall mean registration accuracy was 93.8%±4.9% (range: 80.9% to 99.7%). CONCLUSION: Our validated AR system has the potential to effectively enable the prediction of internal hepatic anatomic structures during 3D laparoscopic liver resection, and may enhance 3D visualization for select laparoscopic liver surgeries.

Effect of Self-Training Using Virtual Reality Head-Mounted Display Simulator on the Acquisition of Holmium Laser Enucleation of the Prostate Surgical Skills.

PURPOSE: We aimed to evaluate the effect of self-training using a virtual reality head-mounted display simulator on the acquisition of surgical skills for holmium laser enucleation surgery. METHODS: Thirteen medical students without surgical skills for holmium laser enucleation of the prostate were trained using multimedia to learn the technique via simulator manipulation. Thereafter, participants performed the technique on a virtual benign prostatic hyperplasia model A (test A). After a 1-week wash-out period, they underwent self-training using a simulator and performed the technique on model B (test B). Subsequently, participants were asked to respond to Training Satisfaction Questions. Video footage of hand movements and endoscope view were recorded during tests A and B for later review by 2 expert surgeons. A 20-step Assessment Checklist, 6-domain Global Rating Scale, and a Pass Rating were used to compare performance on tests A and B. RESULTS: Thirteen participants completed both tests A and B. The 20-step Assessment Checklist and 6-domain Global Rating Scale evaluation results showed significantly improved scores in test B than in test A (P<0.05). No evaluator rated participants as passed after test A, but 11 participants (84.6%) passed after test B. Ten participants (76.9%) indicated that the simulator was helpful in acquiring surgical skills for holmium laser enucleation of the prostate. CONCLUSION: The virtual reality head-mounted display holmium laser enucleation of the prostate simulator was effective for surgical skill training. This simulator may help to shorten the learning curve of this technique in real clinical practice in the future.

Controlling Fluorination Density of Soluble Polyimide Gate Dielectrics and its Influence on Organic Crystal Growth and Device Operational Stability.

Fluorinated polyimides (PIs) are among the most promising candidates for gate dielectric materials in organic electronic devices because of their solution processability and outstanding chemical, mechanical, and thermal stabilities. Additionally, fluorine (F) substitution improves the electrical properties of PI thin films, such as enhanced dielectric properties and reduced surface trap densities. However, the relationship between the fluorination density of PIs and crystal growth modes of vacuum-deposited conjugated molecules on PI thin films, which is directly related to the lateral charge transport along the PI-organic semiconductor interface, has not been systematically studied. Herein, five different soluble PIs with different F densities were synthesized, and the correlation between fluorination and thin-film properties was systematically investigated. Not only were their dielectric properties modulated, but the growth modes of the organic molecules deposited on the PI thin films also changed with increasing surface F density. This phenomenon was observed by both surface and crystallographic analyses, which resulted in extremely high operational stability of field-effect transistors and the successful fabrication of organic complementary circuits. We believe that the correlation between PI backbone fluorination and its thin-film properties will provide practical insights into the material design based on controlled molecular directed surface assembly on fluorinated polymer dielectrics.

Probing Inherent Optical Anisotropy in Substrates via Direct Nanoimaging of Mie Scattering.

In this study, we investigated the optical properties of a transition metal dichalcogenide (TMD) substrate via Mie-scattering-induced surface analysis (MISA). Employing near-field optical microscopy and finite-difference time-domain (FDTD) simulations, we systemically prove and directly visualize the Mie scattering of superspherical gold nanoparticles (s-AuNPs) at the nanoscale. Molybdenum disulfide substrates exhibited optical isotropy, while rhenium disulfide (ReS2) substrates showed anisotropic behavior attributed to the interaction with incident light's electric field. Our study revealed substantial anisotropic trends in Mie scattering, particularly in the near-infrared energy range, with ReS2 exhibiting more pronounced spectral and angular responses in satellite peaks. Our results emphasize the application of Mie scattering, exploring the optical properties of substrates and contributing to a deeper understanding of nanoscale light-matter interactions.

An elementary review on basic principles and developments of qubits for quantum computing.

An elementary review on principles of qubits and their prospects for quantum computing is provided. Due to its rapid development, quantum computing has attracted considerable attention as a core technology for the next generation and has demonstrated its potential in simulations of exotic materials, molecular structures, and theoretical computer science. To achieve fully error-corrected quantum computers, building a logical qubit from multiple physical qubits is crucial. The number of physical qubits needed depends on their error rates, making error reduction in physical qubits vital. Numerous efforts to reduce errors are ongoing in both existing and emerging quantum systems. Here, the principle and development of qubits, as well as the current status of the field, are reviewed to provide information to researchers from various fields and give insights into this promising technology.

Growth Control of InP/ZnSe Heterostructured Nanocrystals.

The morphology of heterostructured semiconductor nanocrystals (h-NCs) dictates the spatial distribution of charge carriers and their recombination dynamics and/or transport, which are the main performance indicators of photonic applications utilizing h-NCs. The inability to control the morphology of heterovalent III-V/II-VI h-NCs composed of heavy-metal-free elements hinders their practical use. As a case study of III-V/II-VI h-NCs, the growth control of ZnSe epilayers on InP NCs is demonstrated here. The anisotropic morphology in InP/ZnSe h-NCs is attributed to the facet-dependent energy costs for the growth of ZnSe epilayers on different facets of InP NCs, and effective chemical means for controlling the growth rates of ZnSe on different surface planes are demonstrated. Ultimately, this article capitalizes on the controlled morphology of InP/ZnSe h-NCs to expand their photophysical characteristics from stable and pure emission to environment-sensitive one, which will facilitate their use in a variety of photonic applications.

Synthesis and Electrochemical Performance of Microporous Hollow Carbon from Milkweed Pappus as Cathode Material of Lithium-Sulfur Batteries.

Microtube-like porous carbon (MPC) and tube-like porous carbon-sulfur (MPC-S) composites were synthesized by carbonizing milkweed pappus with sulfur, and they were used as cathodes for lithium-sulfur batteries. The morphology and uniformity of these materials were characterized using X-ray powder diffraction, Raman spectroscopy, scanning electron microscopy, transmission electron microscopy with an energy-dispersive X-ray analyzer, thermogravimetric analysis, and X-ray photoelectron spectrometry. The electrochemical performance of the MPC-S cathodes was measured using the charge/discharge cycling performance, C rate, and AC impedance. The composite cathodes with 93.8 wt.% sulfur exhibited a stable specific capacity of 743 mAh g-1 after 200 cycles at a 0.5 C.

Low-Dose Three-Dimensional Rotational Angiography for Evaluating Intracranial Aneurysms: Analysis of Image Quality and Radiation Dose.

OBJECTIVE: This study aimed to evaluate the image quality and dose reduction of low-dose three-dimensional (3D) rotational angiography (RA) for evaluating intracranial aneurysms. MATERIALS AND METHODS: We retrospectively evaluated the clinical data and 3D RA datasets obtained from 146 prospectively registered patients (male:female, 46:100; median age, 58 years; range, 19-81 years). The subjective image quality of 79 examinations obtained from a conventional method and 67 examinations obtained from a low-dose (5-seconds and 0.10-µGy/frame) method was assessed by two neurointerventionists using a 3-point scale for four evaluation criteria. The total image quality score was then obtained as the average of the four scores. The image quality scores were compared between the two methods using a noninferiority statistical testing, with a margin of -0.2 (i.e., score of low-dose group - score of conventional group). For the evaluation of dose reduction, dose-area product (DAP) and air kerma (AK) were analyzed and compared between the two groups. RESULTS: The mean total image quality score ± standard deviation of the 3D RA was 2.97 ± 0.17 by reader 1 and 2.95 ± 0.20 by reader 2 for conventional group and 2.92 ± 0.30 and 2.95 ± 0.22, respectively, for low-dose group. The image quality of the 3D RA in the low-dose group was not inferior to that of the conventional group according to the total image quality score as well as individual scores for the four criteria in both readers. The mean DAP and AK per rotation were 5.87 Gy-cm² and 0.56 Gy, respectively, in the conventional group, and 1.32 Gy-cm² (p < 0.001) and 0.17 Gy (p < 0.001), respectively, in the low-dose group. CONCLUSION: Low-dose 3D RA was not inferior in image quality and reduced the radiation dose by 70%-77% compared to the conventional 3D RA in evaluating intracranial aneurysms.

Low-Dose 3D Rotational Angiography in Measuring the Size of Intracranial Aneurysm: In Vitro Feasibility Study Using Aneurysm Phantom.

PURPOSE: Three-dimensional (3D) measurement of intracranial aneurysms is important in planning endovascular treatment, and 3D rotational angiography (RA) is effective in accurate measurement. The purpose of this study was to evaluate the feasibility of low dose 3D RA (5 seconds 0.10 µGy/frame) in measuring an intracranial aneurysm using an in vitro phantom. MATERIALS AND METHODS: We investigated an in vitro 3D phantom of an intracranial aneurysm with 10 acquisitions of 3D RA with a conventional dose (5 seconds 0.36 µGy/frame) and 10 acquisitions with a low-dose (5 seconds 0.10 µGy/frame). 3D size and neck diameters of the aneurysm were measured and compared between the 2 groups (conventional and low-dose) using noninferiority statistics. RESULTS: The aneurysm measurements were well-correlated between the 2 readers, and noninferiority in the measurement of aneurysmal size of low-dose 3D RA was demonstrated, as the upper margin of the 1-sided 97.5% confidence interval did not cross the pre-defined noninferiority margin of 0.2 mm by the 2 readers. CONCLUSION: Low-dose (5 seconds 0.10 µGy/frame) cerebral 3D RA is technically feasible and not inferior in in vitro 3D measurement of an intracranial aneurysm. Thus, low-dose 3D RA is promising and needs further evaluation for its clinical utility in the planning of endovascular treatment of an intracranial aneurysm.

Feasibility of membrane distillation process for potable water reuse: A barrier for dissolved organic matters and pharmaceuticals.

In this study, the feasibility of the membrane distillation (MD) process as a wastewater reclamation system for portable reuse was investigated. The flux was stably maintained at about 20 L/m2h (LMH) at ΔT 30 °C, compared to higher flux at ΔT 50 °C, which showed a rapid decrease in the flux due to severe fouling. MD produced excellent quality of potable water satisfied the drinking water standards of Korea from effluent of sewage treatment plant (ESTP). The fractions of the hydrophobic OC (HOC) and chromatographic DOC (CDOC) from LC-OCD analysis was firstly suggested to understand different organic transport during the MD process. The transport of organic matters across the MD membrane mitigated at low operation temperature and the transported organics in all the tested waters were mostly volatile low molecular weight organics, aromatic amino acids. All of thirteen selected pharmaceuticals were completely removed by MD, regardless of their properties. In order to retard the membrane fouling of the MD process, coagulation and filtration pre-treatments were applied. The pre-treatment process coupled MD process could successfully remove impurities including NH4-N without severe membrane fouling. Moreover, coagulation pretreatment reduced transport of ammonia due to decrease in pH.

Observation of Hong-Ou-Mandel interference with scalable Yb+-photon interfaces.

We present a compact optical design for a scalable trapped ion quantum processor employing a single high numerical aperture lens for the excitation of ions and collection of photons, both of which are essential for remote entanglement generation. We verified the design by performing a quantum interference experiment between two photons generated by two sets of the proposed design and observed a 82(3) % suppression of coincidence within 8.13 ns time window when the two photons became indistinguishable. This design can be extended for the simultaneous generation of multiple pairs of entangled qubits with existing fiber-array devices.

Orthogonal deposition of Au on different facets of Ag cuboctahedra for the fabrication of nanoboxes with complementary surfaces.

We report the fabrication of Ag-Au cuboctahedral nanoboxes enclosed by {100} and {111} facets, respectively, through the orthogonal deposition of Au on two different facets of Ag cuboctahedra. Specifically, we titrate aqueous HAuCl4 into an aqueous mixture containing Ag cuboctahedra, ascorbic acid, and NaOH (under basic conditions), in the presence of poly(vinylpyrrolidone) (PVP) and cetyltrimethylammonium chloride (CTAC), respectively. In the case of PVP, the oxidation of Ag was initiated from the {111} facets of the cuboctahedra through the galvanic replacement reaction between Au(iii) and Ag, accompanied by the deposition of Au onto the {100} facets. Because the dissolved Ag(i) ions could react with NaOH to form Ag2O on the {111} facets and thus terminate the galvanic reaction, the Au(iii) ions would be further reduced by the ascorbate monoanion (HAsc-) to generate Au atoms for their continuing deposition on the {100} facets, converting Ag cuboctahedra to Ag@Au{100} cuboctahedra. Upon the etching of Ag from the core, we obtained Ag-Au cuboctahedral nanoboxes enclosed by {100} facets. In contrast, when CTAC was present, the oxidation of Ag through a galvanic reaction could continuously proceed on {100} facets as the dissolved Ag(i) ions would react with the excessive amount of Cl- ions derived from CTAC to produce soluble AgCl2- ions rather than insoluble Ag2O. As a result, the dissolved Ag(i) and Au(iii) ions would be co-reduced by HAsc- for the generation of Ag and Au atoms, followed by their co-deposition onto {111} facets for the generation of Ag@Au{111} concave cuboctahedra. After the removal of Ag from the core by etching, we obtained Ag-Au{111} cuboctahedral nanoboxes enclosed by {111} facets. Both samples of cuboctahedral nanoboxes exhibited strong optical absorption in the infrared region. Interestingly, the cuboctahedral nanoboxes enclosed by {111} facets showed significantly enhanced catalytic activity toward the reduction of 4-nitrophenol by NaBH4 relative to their counterparts encased by {100} facets.

Observation of scalable sub-Poissonian-field lasing in a microlaser.

Sub-Poisson field with much reduced fluctuations in a cavity can boost quantum precision measurements via cavity-enhanced light-matter interactions. Strong coupling between an atom and a cavity mode has been utilized to generate highly sub-Poisson fields. However, a macroscopic number of optical intracavity photons with more than 3 dB variance reduction has not been possible. Here, we report sub-Poisson field lasing in a microlaser operating with hundreds of atoms with well-regulated atom-cavity coupling and interaction time. Its photon-number variance was 4 dB below the standard quantum limit while the intracavity mean photon number scalable up to 600. The highly sub-Poisson photon statistics were not deteriorated by simultaneous interaction of a large number of atoms. Our finding suggests an effective pathway to widely scalable near-Fock-state lasing at the macroscopic scale.

Room temperature continuous-wave nanolaser diode utilized by ultrahigh-Q few-cell photonic crystal nanocavities.

Few-cell point-defect photonic crystal (PhC) nanocavities (such as LX and H1 type cavities), have several unique characteristics including an ultra-small mode volume (Vm), a small device footprint advantageous for dense integration, and a large mode spacing advantageous for high spontaneous-emission coupling coefficient (ß), which are promising for energy-efficient densely-integratable on-chip laser light sources enhanced by the cavity QED effect. To achieve this goal, a high quality factor (Q) is essential, but conventional few-cell point-defect cavities do not have a sufficiently high Q. Here we adopt a series of modified designs of LX cavities with a buried heterostructure (BH) multi-quantum-well (MQW) active region that can achieve a high Q while maintaining their original advantages and fabricate current-injection laser devices. We have successfully observed continuous-wave (CW) lasing in InP-based L1, L2, L3 and L5 PhC nanocavities at 23°C with a DC current injection lower than 10 µA and a bias voltage lower than 0.9 V. The active volume is ultra-small while maintaining a sufficiently high confinement factor, which is as low as ~10-15 cm3 for a single-cell (L1) nanocavity. This is the first room-temperature current-injection CW lasing from any types of few-cell point-defect PhC nanocavities (LX or H1 types). Our report marks an important step towards realizing a nanolaser diode with a high cavity-QED effect, which is promising for use with on-chip densely integrated laser sources in photonic networks-on-chip combined with CMOS processors.

Cranioplasty Using Autologous Bone versus Porous Polyethylene versus Custom-Made Titanium Mesh : A Retrospective Review of 108 Patients.

OBJECTIVE: The purpose of this study was to compare the cosmetic outcome and complications after cranioplasty (CP) due to three different implant materials, and analyze the mean implant survival and cumulative survival rate based on these results. METHODS: We reviewed 108 patients retrospectively who underwent CP between January 2014 and November 2016. Autologous bone (AB; 45 patients) and synthetic materials with porous polyethylene (PP; 32 patients) and custom-made 3-dimensional printed titanium mesh (CT; 31 patients) were used as implants. RESULTS: Regardless of implanted materials, more than 89.8% of the CP patients were satisfied with the cosmetic outcome. No statistically significant difference was observed among the three groups. The overall postoperative complication rates of each group were 31.1% in the AB group, 15.6% in the PP group and 3.2% in the CT group. The CT group showed lower complication rates compared with AB and PP groups (χ2-test : AB vs. PP, p=0.34; AB vs. CT, p=0.00; PP vs. CT, p=0.03). The AB and PP groups demonstrated a higher post-CP infection rate (11.1% and 6.3%) than the CT group (3.2%). However, no significant difference in the incidence of post-CP infection was observed among the three groups. The PP and CT groups demonstrated a higher mean implant survival time and cumulative survival rate than the AB group at the last follow-up (p<0.05). CONCLUSION: In comparison with AB and PP, cranioplasty with CT shows benefits in terms of lower post-CP complication, less intraoperative bleeding loss, shorter operation time and in-hospital stay. The PP and CT groups showed higher implant survival time and cumulative survival rate compared with the AB group.

Identification of Cystoisospora ohioensis in a Diarrheal Dog in Korea.

A 3-month-old female Maltese puppy was hospitalized with persistent diarrhea in a local veterinary clinic. Blood chemistry and hematology profile were analyzed and fecal smear was examined. Diarrheal stools were examined in a diagnostic laboratory, using multiplex real-time polymerase chain reaction (PCR) against 23 diarrheal pathogens. Sequence analysis was performed using nested PCR amplicon of 18S ribosomal RNA. Coccidian oocysts were identified in the fecal smear. Although multiplex real-time PCR was positive for Cyclospora cayetanensis, the final diagnosis was Cystoisospora ohioensis infection, confirmed by phylogenetic analysis of 18S rRNA. To our knowledge, this the first case report of C. ohioensis in Korea, using microscopic examination and phylogenetic analysis.

Facet-selective deposition of Au and Pt on Ag nanocubes for the fabrication of bifunctional Ag@Au-Pt nanocubes and trimetallic nanoboxes.

We report a facile route to the synthesis of Ag@Au-Pt trimetallic nanocubes in which the Ag, Au, and Pt atoms are exposed at the corners, side faces, and edges, respectively. Our success relies on the use of Ag@Au nanocubes, with Ag2O patches at the corners and Au on the side faces and edges, as seeds for the site-selective deposition of Pt on the edges only in a reaction system containing ascorbic acid (H2Asc) and poly(vinylpyrrolidone). At an initial pH of 3.2, H2Asc can dissolve the Ag2O patches, exposing the Ag atoms at the corners of a nanocube. Upon the injection of the H2PtCl6 precursor, the Pt atoms derived from the reduction by both H2Asc and Ag are preferentially deposited on the edges, leading to the formation of Ag@Au-Pt trimetallic nanocubes. We demonstrate the use of 2,6-dimethylphenyl isocyanide as a molecular probe to confirm and monitor the deposition of Pt atoms on the edges of nanocubes through surface-enhanced Raman scattering (SERS). We further explore the use of these bifunctional trimetallic nanoparticles with integrated plasmonic and catalytic properties for in situ SERS monitoring the reduction of 4-nitrothiophenol by NaBH4. Upon the removal of Ag via H2O2 etching, the Ag@Au-Pt nanocubes evolve into trimetallic nanoboxes with a wall thickness of about 2 nm and well-defined openings at the corners. The trimetallic nanoboxes embrace plasmon resonance peaks in the near-infrared region with potential in biomedical applications.

Coherent single-atom superradiance.

Superradiance is a quantum phenomenon emerging in macroscopic systems whereby correlated single atoms cooperatively emit photons. Demonstration of controlled collective atom-field interactions has resulted from the ability to directly imprint correlations with an atomic ensemble. Here we report cavity-mediated coherent single-atom superradiance: Single atoms with predefined correlation traverse a high-quality factor cavity one by one, emitting photons cooperatively with the N atoms that have already gone through the cavity (N represents the number of atoms). Enhanced collective photoemission of N-squared dependence was observed even when the intracavity atom number was less than unity. The correlation among single atoms was achieved by nanometer-precision position control and phase-aligned state manipulation of atoms by using a nanohole-array aperture. Our results demonstrate a platform for phase-controlled atom-field interactions.

Gold-Based Cubic Nanoboxes with Well-Defined Openings at the Corners and Ultrathin Walls Less Than Two Nanometers Thick.

We report a facile synthesis of Au-based cubic nanoboxes as small as 20 nm for the outer edge length, together with well-defined openings at the corners and walls fewer than 10 atomic layers (or <2 nm) in thickness. The success relies on the selective formation of Ag2O at the corners of Ag nanocubes, followed by the conformal deposition of Au on the side faces in a layer-by-layer fashion. When six atomic layers of Au are formed on the side faces to generate Ag@Au6L core-shell nanocubes, we can selectively remove the Ag2O patches at the corner sites using a weak acid, making it possible to further remove the Ag core by H2O2 etching without breaking the ultrathin Au shell. This synthetic approach works well for Ag nanocubes of 38 and 18 nm in edge length, and the wall thickness of the nanoboxes can be controlled down to 2 nm. The resultant Au nanoboxes exhibit strong plasmonic absorption in the near-infrared region, consistent with computational simulations.

Three-dimensional imaging of cavity vacuum with single atoms localized by a nanohole array.

Zero-point electromagnetic fields were first introduced to explain the origin of atomic spontaneous emission. Vacuum fluctuations associated with the zero-point energy in cavities are now utilized in quantum devices such as single-photon sources, quantum memories, switches and network nodes. Here we present three-dimensional (3D) imaging of vacuum fluctuations in a high-Q cavity based on the measurement of position-dependent emission of single atoms. Atomic position localization is achieved by using a nanoscale atomic beam aperture scannable in front of the cavity mode. The 3D structure of the cavity vacuum is reconstructed from the cavity output. The root mean squared amplitude of the vacuum field at the antinode is also measured to be 0.92±0.07 V cm(-1). The present work utilizing a single atom as a probe for sub-wavelength imaging demonstrates the utility of nanometre-scale technology in cavity quantum electrodynamics.