Bionic artificial skin with a fully implantable wireless tactile sensory system for wound healing and restoring skin tactile function.

Tactile function is essential for human life as it enables us to recognize texture and respond to external stimuli, including potential threats with sharp objects that may result in punctures or lacerations. Severe skin damage caused by severe burns, skin cancer, chemical accidents, and industrial accidents damage the structure of the skin tissue as well as the nerve system, resulting in permanent tactile sensory dysfunction, which significantly impacts an individual's daily life. Here, we introduce a fully-implantable wireless powered tactile sensory system embedded artificial skin (WTSA), with stable operation, to restore permanently damaged tactile function and promote wound healing for regenerating severely damaged skin. The fabricated WTSA facilitates (i) replacement of severely damaged tactile sensory with broad biocompatibility, (ii) promoting of skin wound healing and regeneration through collagen and fibrin-based artificial skin (CFAS), and (iii) minimization of foreign body reaction via hydrogel coating on neural interface electrodes. Furthermore, the WTSA shows a stable operation as a sensory system as evidenced by the quantitative analysis of leg movement angle and electromyogram (EMG) signals in response to varying intensities of applied pressures.

Photothermal Lithography for Realizing a Stretchable Multilayer Electronic Circuit Using a Laser.

Photolithography is a well-established fabrication method for realizing multilayer electronic circuits. However, it is challenging to adopt photolithography to fabricate intrinsically stretchable multilayer electronic circuits fully composed of an elastomeric matrix, due to the opacity of thick stretchable nanocomposite conductors. Here, we present photothermal lithography that can pattern elastomeric conductors and via holes using pulsed lasers. The photothermal-patterned stretchable nanocomposite conductor exhibits 3 times higher conductivity (5940 S cm-1) and 5 orders of magnitude lower resistance change (R/R0 = 40) under a 30% strained 5000th cyclic stretch, compared to those of a screen-printed conductor, based on the percolation network formed by spatial heating of the laser. In addition, a 50 µm sized stretchable via holes can be patterned on the passivation without material ablation and electrical degradation of the bottom conductor. By repeatedly patterning the conductor and via holes, highly conductive and durable multilayer circuits can be stacked with layer-by-layer material integration. Finally, a stretchable wireless pressure sensor and passive matrix LED array are demonstrated, thus showing the potential for a stretchable multilayer electronic circuit with durability, high density, and multifunctionality.

Photopatternable Poly(dimethylsiloxane) (PDMS) for an Intrinsically Stretchable Organic Electrochemical Transistor.

Patterning elastomers is an essential process for the application of elastomers to stretchable bioelectric devices. In general, replication of a mold and laser ablation are used for patterning elastomers. However, these methods are inefficient and time consuming due to complex patterning procedures and a heat-induced curing mechanism. In this work, we developed a photopatternable elastomer called thiol-ene cross-linked poly(dimethylsiloxane) (TC-PDMS). TC-PDMS showed high-resolution patternability (∼100 µm) through a direct patterning process. It also had high stretchability (∼140%) and low Young's modulus (∼2.9 MPa) similar to conventional PDMS. To demonstrate its practicability in stretchable bioelectric devices, TC-PDMS was applied to a passivation layer of an intrinsically stretchable organic electrochemical transistor (OECT), which showed a low leakage current (∼20 µA) and a high transconductance (0.432 mS) at high strain (60%). The stretchable OECT was able to record electrocardiographic (ECG) signals from human skin, and the measured ECG signals exhibited a high signal-to-noise ratio of 12.2 dB.

Hierarchically Structured Laser-Induced Graphene for Enhanced Boiling on Flexible Substrates.

Thermal management problems in high-power flexible electronics are exacerbated by the design complexity and requirement of stringent temperature control to prevent skin burns. Thus, effective heat dissipation methods applicable to flexible electronics on polymer substrates are an essential device design component. Accordingly, this study investigates the pool boiling heat transfer characteristics and potential enhancements, enabled by laser-induced graphene (LIG), which is both highly porous and bendable. Patterned LIG with a mesh spacing of 200 µm was formed on flexible polyimide substrates by laser direct writing, and the resulting surfaces exhibited enhanced heat transfer characteristics. Pool boiling experiments were conducted with an FC-72 working fluid to investigate the heat removal capability of LIG, and its performance was further improved by separating the liquid supply passages from the vapor escape routes. Overall, the inclusion of LIG resulted in a 2- to 3-fold increase in both the critical heat flux (33.6 W/cm2) and heat transfer coefficient (7.6 kW/(m2·K)), compared to pristine polyimide films.