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[Diagnosis and treatment of obstructive jaundice]. / Diagnostika i lechenie mekhanicheskoi zheltukhi.

Kochnev, O S; Kim, I A; Kim, V Kh; Valeev, A G.

Khirurgiia (Mosk) ; (8): 19-22, 1983 Aug.

Article in Russian | MEDLINE | ID: mdl-6226822

Subject(s)

Cholestasis/diagnosis , Adult , Aged , Cholestasis/surgery , Diagnosis, Differential , Drainage , Female , Humans , Laparoscopy , Liver/pathology , Male , Middle Aged

[Comparative study of the toxicity and antitumor activity of a DNA-rubomycin complex and free rubomycin]. / Sravnitel'noe izuchenie toksichnosti i protivoopukholevoi aktivnosti kompleksa DNK-rubomitsin i svobodnogo rubomitsina.

Kim, V Kh; Smoryzanova, O A; Riabchenko, N I; Dedenkov, A N.

Antibiotiki ; 26(5): 361-5, 1981 May.

Article in Russian | MEDLINE | ID: mdl-7259142

Subject(s)

Antineoplastic Agents , DNA/toxicity , Daunorubicin/toxicity , Animals , Carcinoma, Ehrlich Tumor/drug therapy , DNA/therapeutic use , Daunorubicin/therapeutic use , Dose-Response Relationship, Drug , Drug Combinations , Drug Evaluation, Preclinical , Mice , Rats , Thymus Gland/drug effects , Time Factors

[Effect of a DNA-rubomycin complex on the molecular mass, radiosensitivity and reparation of gamma-induced single-stranded breaks in the DNA of sarcoma 180 cells]. / Vliianie kompleksa DNK-rubomitsin na molekuliarnuiu massu, radiochuvstvitel'nost'i reparatsiiu gamma-indutsirovannykh odnonitevykh razryvov v DNK kletok sarkomy 180.

Proskuriakov, S Ia; Ivannik, B P; Smoryzanova, O A; Kim, V Kh; Dedenkov, A N.

Antibiotiki ; 24(5): 368-72, 1979 May.

Article in Russian | MEDLINE | ID: mdl-443795

ABSTRACT

The use of the DNA-rubomycin complex resulted in appearance of one-thread breaks (OB) in DNA and markedly increased the number of the DNA OB determined immediately after irradiation. The DNA-rubomycin complex decreased the volume of the repaired OB and induced postreparation degradation of the one-bond DNA (oDNA) in the sarcoma 180 cells. The effect of the decrease in the molecular mass of the oDNA 6 hours after the irradiation to the level of the initial damage is probably in favour of the fact that degradation takes place in the areas of the repaired breaks. The data indicated that the viscosimetric method for the analysis of the OB in DNA may be promising in estimation of the efficacy of radiation and chemotherapy of solid tumors.

Subject(s)

DNA Repair/drug effects , DNA, Neoplasm/radiation effects , DNA, Single-Stranded/radiation effects , DNA/therapeutic use , Daunorubicin/therapeutic use , Radiation Tolerance , Sarcoma 180/therapy , Animals , Dose-Response Relationship, Radiation , Drug Combinations , Drug Evaluation, Preclinical , Gamma Rays/therapeutic use , Male , Mice , Molecular Weight , Neoplasm Transplantation , Time Factors

[Effect of exogenous thyrocalcitonin on the growth of an irradiated adenocarcinoma-755]. / Vliianie ékzogennogo tirokaltsitonina na rost adenokartsinomy-755.

Nikitenko, V A; Kim, V Kh.

Med Radiol (Mosk) ; 23(10): 56-8, 1978 Oct.

Article in Russian | MEDLINE | ID: mdl-703549

Subject(s)

Adenocarcinoma/radiotherapy , Calcitonin/therapeutic use , Adenocarcinoma/drug therapy , Animals , Cell Division/drug effects , Drug Evaluation, Preclinical , Female , Mice , Neoplasm Transplantation , Neoplasms, Experimental/drug therapy , Neoplasms, Experimental/radiotherapy

[Relation of the therapeutic effect of exogenous DNA to dose when administered to irradiated mice]. / Zavisimost' lechebnogo éffekta ékzogennoi DNK ot dozy pri vvedenii obluchennym mysham.

Kim, V Kh; Ivannik, B P; Riabchenko, N I.

Radiobiologiia ; 17(1): 8-11, 1977.

Article in Russian | MEDLINE | ID: mdl-897113

Subject(s)

DNA/administration & dosage , Radiation Injuries, Experimental/drug therapy , Animals , DNA/therapeutic use , Dose-Response Relationship, Drug , Female , Male , Mice

[Isoenzymes of acid phosphatase and esterase in ortho-aminoazotoluene-induced hepatomas]. / Izofermenty kisloi fosfatazy i esterazy gepatom, indutsirovannykh ortoaminoazotoluolom

Surinov, B P; Lavrinetskaia, T E; Kim, V Kh; Kulish, Iu S; Filatov, P P.

Vopr Onkol ; 22(12): 79, 1976.

Article in Russian | MEDLINE | ID: mdl-190796

Subject(s)

Acid Phosphatase/metabolism , Carcinoma, Hepatocellular/enzymology , Esterases/metabolism , Isoenzymes/metabolism , Liver Neoplasms/enzymology , Animals , Carcinoma, Hepatocellular/chemically induced , Liver Neoplasms/chemically induced , Mice , Neoplasms, Experimental/chemically induced , Neoplasms, Experimental/enzymology , o-Aminoazotoluene

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