ABSTRACT
Radixin (RDX) is part of the ezrin-radixin-moesin (ERM) protein family. It functions as a membrane-cytoskeletal linker in actin-rich cell surface structures and is thought to be essential for cortical cytoskeleton organization, cell motility, adhesion, and proliferation. An increase in phosphorylated ERM in fibroblast-like synoviocytes contributes to rheumatoid arthritis (RA) synovial hyperplasia. We examined the genetic association between the RDX gene and RA in a Korean population. To identify the relationship between RDX gene polymorphisms and RA, we genotyped 2 single nucleotide polymorphisms (SNPs; rs11213326 and rs12575162) of RDX using a direct sequencing method in 296 RA patients and 493 control subjects. In this study, the 2 SNPs showed no association with RA disease susceptibility. However, further analysis based on clinical information of the RA patient group showed that the SNPs were associated with the erythrocyte sedimentation rate (ESR) in RA patients. These data suggest an association between RDX polymorphisms and the clinical features of RA patients, particularly the ESR.
Subject(s)
Arthritis, Rheumatoid/genetics , Blood Sedimentation , Cytoskeletal Proteins/genetics , Genetic Association Studies , Membrane Proteins/genetics , Adult , Arthritis, Rheumatoid/pathology , Asian People , Case-Control Studies , Female , Genetic Predisposition to Disease , Genotype , Humans , Male , Middle Aged , Polymorphism, Single Nucleotide , Population , Republic of KoreaABSTRACT
Renal subcapsular abscess is a very rare entity that is defined by a suppurative process localized to a space between the renal capsule and the renal parenchyma. The pathogenesis and aetiology of this entity remain speculative. To our knowledge, only five cases have been reported in the English literature. We describe a 74-year old woman with renal subcapsular abscess treated with laparoscopic removal and do a review of the literature.
El absceso renal subcapsular es una entidad muy rara que se define por un proceso supurativo localizado en un espacio entre la cápsula renal y el parénquima renal. La patogénesis y la etiología de esta entidad siguen siendo asunto de especulación. Hasta donde sabemos, solamente cinco casos han sido reportados en la literatura inglesa. Describimos aquí a una mujer de 74 años de edad con un absceso renal subcapsular tratado con extirpación laparoscópica y hacemos a la par una revisión de la litera-tura