ABSTRACT
Immunoglobulin gamma (Ig) type 4-related disease (IgG4-RD) is a chronic immunologic systemic disorder that has gained worldwide recognition in the past decade. This entity can affect almost every organ system, and its characteristic lesions have been found in a variety of organs such as lacrimal and salivary glands, pancreas, liver, bile ducts, lungs, kidneys, retroperitoneum, breast, aorta, thyroid, and prostate. This case reports a very rare case of IgG4-RD presenting with a cutaneous lesion in a young female patient mimicking a lymphoproliferative disorder. IgG4-RD affecting the skin is a rare entity and has mostly been reported in Japanese men of middle to older age. IgG4-RD with cutaneous involvement should be in the differential of non-neoplastic, lymphomas, autoimmune, and infectious disorders of the skin.
Subject(s)
Autoimmune Diseases/pathology , Immunoglobulin G4-Related Disease/immunology , Immunoglobulin G4-Related Disease/pathology , Pseudolymphoma/pathology , Skin Diseases/pathology , Adolescent , Autoimmune Diseases/immunology , Biopsy, Needle , Diagnosis, Differential , Female , Humans , Immunoglobulin G4-Related Disease/diagnosis , Immunohistochemistry , Pseudolymphoma/diagnosis , Rare Diseases , Skin Diseases/immunology , Thigh/pathology , White PeopleABSTRACT
Infantile hemangiomas (IHs) with minimal or arrested growth differ from standard IHs in that they have a reduced or absent growth phase. An association between IHs with minimal or arrested growth and superimposed eczematous dermatitis has not been described in the literature. We present a case detailing this association in which an IH with minimal or arrested growth responded well to treatment with propranolol and the superimposed eczema cleared completely with topical hydrocortisone.
