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Bioorg Med Chem Lett
; 16(8): 2260-5, 2006 Apr 15.
Article
in English
| MEDLINE
| ID: mdl-16455256
ABSTRACT
A novel series of potent blockers of the monocarboxylate transporter, MCT1, is disclosed. From very potent but lipophilic lead compounds, systematic changes to all parts of the molecule, targeting reduction in log D, afforded compounds with significantly improved overall properties. These compounds show potent immunomodulatory activity.