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2.
Pediatr Infect Dis J ; 32(7): 715-22, 2013 Jul.
Article in English | MEDLINE | ID: mdl-23429557

ABSTRACT

BACKGROUND: Intrathecal baclofen (ITB) is an effective therapy for spasticity and dystonia in pediatric populations; however, there are associated infectious complications. METHODS: Patients who had an initial ITB device implanted at our center were followed to determine the proportion of patients with infectious and noninfectious complications, identify risk factors for infection and describe the clinical presentations, treatment and outcomes of infectious complications. RESULTS: Over the 15-year study period, 139 patients had an initial ITB device placed. The mean age at placement was 13.6 years (range: 6 months to 41 years). In the first year of follow-up, 83% had no complications or secondary procedures, 17% had at least 1 secondary procedure and 5% had an infectious complication. The median time until infection was 14 days (mean 33 ± 42 days). Patients with secondary spasticity or dystonia were more likely to have infections than patients with cerebral palsy (86% versus 14%; P < 0.0001). In the 94 patients with a first secondary procedure, 29% had at least 1 other procedure and 8% had an infection in the 1 year follow-up. Overall, 24 patients had 27 infections; 22% superficial, 33% deep and 45% organ space. Staphylococcus aureus was isolated in 50% of those with cultures obtained. Explantation was required in 59% of patients with an infection and differed by infection type: superficial (17%), deep (44%) and organ space (92%) (P = 0.004). CONCLUSIONS: Infectious complications were relatively uncommon; however, when present, frequently led to the explantation of the ITB pump device.


Subject(s)
Baclofen/administration & dosage , Catheter-Related Infections/epidemiology , Infusion Pumps/adverse effects , Injections, Spinal/adverse effects , Muscle Relaxants, Central/administration & dosage , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Infant , Male , Prevalence , Retrospective Studies , Young Adult
3.
J Pediatr Orthop ; 31(2): 194-204, 2011 Mar.
Article in English | MEDLINE | ID: mdl-21307715

ABSTRACT

BACKGROUND: Few studies exist with regard to the ability of electromyography (EMG) and volumetric magnetic resonance imaging (MRI) of the infraspinatus muscle to complement the physical assessment of active global shoulder external rotation (GER) in the neonatal brachial plexus palsy (NBPP) population. Therefore, the purpose of this study was to evaluate the relationships of EMG and MRI with active GER based on analysis of the infraspinatus muscle. METHODS: Seventy-four NBPP patients (mean age, 5 y 1 m; range, 1 y 1 m to 13 y 3 m) who had undergone physical examination of the shoulder, EMG evaluation of the infraspinatus muscle, and shoulder MRI were included in this study. The outcome variable active GER was dichotomized into <0 degree active GER (poor) and ≥0 degree active GER (good). The interference pattern on EMG of the infraspinatus muscle was graded on a 6-point scale and dichotomized into ≤4 and ≥5. On shoulder MRI, infraspinatus muscle volume was measured. The infraspinatus muscle interference pattern and volume were compared with active GER. RESULTS: Interference pattern on EMG of the infraspinatus muscle was significantly related to the Mallet Score (P=0.0022), with a poor interference pattern associated with an approximately 7 times higher likelihood [odds ratio=7.391; 95% confidence interval (2.054, 26.588)] of poor active GER. Infraspinatus muscle volume decrease on MRI was also significantly related to active GER (P=0.0413), with each percent volume decrease corresponding to an increase of 0.094 in the odds of having a poor Mallet Score for active GER [odds ratio=1.094; 95% confidence interval (1.004, 1.193)]. CONCLUSIONS: The interference pattern of the infraspinatus muscle on EMG and the infraspinatus muscle volume on MRI are strongly related to active GER as assessed by the Mallet Score. Integrating clinical assessment with electrophysiological and imaging findings may improve the accuracy in evaluating shoulder dysfunction in NBPP and provide improved guidance in selecting interventions specific to the patient's pattern of deficits. LEVEL OF EVIDENCE: Diagnostic study, level II.


Subject(s)
Brachial Plexus Neuropathies/complications , Electromyography/methods , Magnetic Resonance Imaging/methods , Shoulder Joint/physiopathology , Adolescent , Birth Injuries/complications , Child , Child, Preschool , Female , Humans , Male , Range of Motion, Articular , Retrospective Studies , Rotation
4.
Pediatr Neurol ; 42(6): 455-8, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20472203

ABSTRACT

A 2-year-old girl with Pompe disease developed an acute worsening of muscle weakness during a hospitalization, and required intubation for an upper respiratory infection. Electromyography and nerve conduction studies produced results consistent with a severe chronic motor axonal peripheral polyneuropathy, with no evidence of reinnervation. Magnetic resonance imaging of the brain demonstrated generalized hypomyelination and parenchymal volume loss, whereas magnetic resonance spectroscopy suggested neuronal injury and hypomyelination. This case provides compelling evidence for a slowly progressive neurodegenerative process in patients with infantile Pompe disease, affecting the motor neurons. Routine electromyography, nerve conduction studies, and cranial magnetic resonance imaging should be considered to delineate the presence of a neurodegenerative process in infantile-onset Pompe disease.


Subject(s)
Brain/pathology , Glycogen Storage Disease Type II/physiopathology , Muscle Weakness/physiopathology , Nerve Fibers, Myelinated/pathology , Disease Progression , Electromyography , Fatal Outcome , Female , Glycogen Storage Disease Type II/pathology , Humans , Infant , Magnetic Resonance Imaging , Muscle Weakness/pathology , Muscle, Skeletal/pathology , Muscle, Skeletal/physiopathology , Respiratory Paralysis/pathology , Respiratory Paralysis/physiopathology
6.
J Am Acad Dermatol ; 46(3): 444-6, 2002 Mar.
Article in English | MEDLINE | ID: mdl-11862186

ABSTRACT

Hyperhidrosis is a relatively common condition with a multitude of causes. Spinal cord injury may be complicated by hyperhidrosis. Many forms of therapy have been reported for this phenomenon but few have been demonstrated to be efficacious. We describe a case of a child with hyperhidrosis from a spinal cord injury and report the first therapeutic use, to our knowledge, of gabapentin for hyperhidrosis.


Subject(s)
Acetates/therapeutic use , Amines , Anticonvulsants/therapeutic use , Cyclohexanecarboxylic Acids , Hematoma, Epidural, Cranial/complications , Hyperhidrosis/etiology , Spinal Cord Injuries/complications , gamma-Aminobutyric Acid , Child , Female , Gabapentin , Humans , Hyperhidrosis/drug therapy
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