Oral 1,25(OH)2D3 pulse therapy for the treatment of secondary hyperparathyroidism.

We examined the effect of oral 1,25(OH)2D3 pulse therapy in hemodialyzed patients with secondary hyperparthyroidism (2 degrees HPT). Prescription of 6.0 micrograms 1,25(OH)2D3 once a week combined with calcium carbonate as a phosphate binder during the last 5 days a week for 12 weeks resulted in improvement of mild to moderate 2 degrees HPT despite no significant differences in serum total calcium and phosphate concentration. In addition, the effect was greater in cases with mild 2 degrees HPT. A single administration of 6 micrograms 1,25(OH)2D3 reduced the parathyroid hormone concentration in patients with mild 2 degrees HPT or with a short duration of hemodialysis. Tmax of the serum 1,25(OH)2D3 after single administration of 6.0 micrograms 1,25(OH)2D3 was individually different (range, 0.4-20.9 hrs). It is recommended that early employment of oral 1,25(OH)2D3 pulse therapy be undertaken once a week combined with prescription of calcium salt as a phosphate binder during the last 5 days a week for the treatment of 2 degrees HPT refractory to conventional therapy, since there is no risk of aluminum accumulation with satisfactory control of the serum total calcium and phosphate concentration.

Two cases of simple bone cyst suspected of being odontogenic tumors.

We report here two cases of simple bone cyst suspected of odontogenic tumors. The first case, a 17-year-old female, was introduced to our department by a dental practitioner because of a large radiographic defect of the bone. The patient had no subjective symptoms. The defect extended between 3 and the ascending ramus, and had multilocular radiolucency associated with bone expansion. The Marsupialization and curettage of the defect were performed. One year after the surgery, the defect was filled with new bone. The second case, a 14-year-old male, complained of occlusal pain in the anterior mandible. Irregular and unilocular radiolucency was seen radiographically in 4 + 2. The biopsy suggested an ossifying fibroma. Extirpation and curettage of the lesion were performed. Ten months after the surgery, the bone expansion disappeared.