The power of human touch: Physical contact improves performance in basketball free throws.

How pervasive is the power of human touch? Physical touch by other humans shows social support and alleviates stress - stress that may otherwise interfere with performance in athletic tasks. We argue that physical touch improves performance in highly stressful situations: free throws in basketball. In two studies (Ntotal = 60 NCAAW games, ktotal = 835 free throw tandems), we assessed how often teammates touched the shooting player (e.g., a tap on the shoulder) in between shooting two free throws. We find that the extent of touch (i.e., being touched by 0, 1, 2, 3, or all 4 teammates) after the first free throw predicted success with the second free throw, but only when players missed the first free throw (integrated data analysis: main effect hand taps: b = 0.47, p = .021; main effect first free throw: b = 1.36, p = .019; interaction effect: b = -0.55, p = .024). We argue that this means that teammates' support expressed in physical touch helps particularly when stress levels are already high. Results are robust when controlling for players' skill level, home versus away games, point difference, and remaining playing time. More frequent touch was also tendentially associated with teams' season success (ACC-teams only, main effect of hand taps: b = -0.42, p = .062). Physical touch thus indeed boosts performance under stress, superseding a range of other factors, likely also in other team sports and interpersonal relationships.

It will (never) stop hurting: Do repeated or chronic experiences of exclusion lead to hyper- or hyposensitive psychological responses?

Unlike one-time lab manipulations of exclusion, in real life, many people experience exclusion, from others and from groups, over extended periods, raising the question of whether individuals could, over time, develop hypo- or hypersensitive responses to chronic exclusion. In Study 1, we subjected participants to repeated experiences of inclusion or exclusion (three Cyberball games, time lag of three days, N = 194; 659 observations). We find that repeatedly excluded individuals become hypersensitive to inclusion, but not to exclusion. Study 2 (N = 183) tested whether individuals with chronic experiences of real-world exclusion show hypo- or hypersensitive responses to a novel episode of exclusion. In line with Study 1, exclusion hurt to the same extent regardless of baseline levels of chronic exclusion in daily life. However, chronically excluded individuals show more psychological distress in general. We discuss theoretical and practical implications for dealing with chronically excluded individuals and groups.

Small molecule targeting of the p38/Mk2 stress signaling pathways to improve cancer treatment.

PURPOSE: Although a long-term goal of cancer therapy always has been the development of agents that selectively destroy cancer cells, more recent trends have been to seek secondary agents that sensitize cancer cells to existing treatment regimens. In this regard, the present study explored the possibility of using small molecule inhibitors of p38MAPK/MK2 stress signaling pathways as potential agents to enhance the sensitivity of cancer cells with abrogated G1 checkpoint to the DNA damaging agent etoposide by specifically targeting the DNA damage-induced G2 cell cycle checkpoint. METHODS: We have applied CCK8 and FACS-based viability assays and cell cycle analysis to investigate the effect of small molecules SB203580 and MK2.III on the sensitivity of small cell lung cancer cells (SCLC) that lack the G1 checkpoint to the DNA damaging agent Etoposide when used in combination. We have also assessed the effectiveness of combination chemotherapy on tumor xenograft suppression with etoposide and MK2.III in immunosuppressed mice. In addition, additional CCK8 cell viability analysis of the MDA-MB-231 breast cancer cell line, and SW620, and SW480 colorectal cancer cell lines was performed. RESULTS: Results suggest that etoposide produces a profound effect on the cell cycle profile of cells in a manner that is consistent with the degree of cell viability that is seen using the viable cell assay. Results of the co-treatment experiments revealed that the p38/MK2 kinase inhibitors SB203580 and MK2.III both enhanced the DNA-damaging effects of etoposide on NCI-H69 cell viability in vitro. Results revealed that in vivo MK2.III was able to act as a chemosensitizer when used in combination with etoposide making NCI-H69 lung cancer cells sensitive to chemotherapeutic drug by 45% compared to single usage of the drug. We also report that MK2.III sensitizes metastatic cell lines SW-620 and MDA-MB-231 to etoposide but does not increase the sensitivity of non-metastasizing SW-480 colorectal cells to DNA damaging agent in vitro. CONCLUSION: Findings reported in this study provide evidence that specific inhibitors of MK2 may indeed improve overall cancer therapy; however, their effectiveness depends on cell types.

Ostracism and social exclusion: Implications for separation, social isolation, and loss.

Ostracism-being ignored and excluded-has received considerable experimental research attention over the last 25 years. Ostracism signals social separation, isolation, and loss, and responses vary across time. Ostracism episodes as short as 2 min result in physiological pain responses, need threat, and emotional distress, followed by cognitive, emotional, motivational, and behavioral responses that either increase the likelihood of subsequent inclusion (at the cost of being socially pliable), or ensure further ostracism through aggression or solitude. Longer-term ostracism leads to resignation, accompanied by alienation, depression, helplessness, and feelings of unworthiness of attention by others. This review focuses on current research on factors that prolong the isolation and loss associated with ostracism, and on interventions that may speed recovery.

Emotional experiences of ghosting.

Although ghosting (i.e., unilaterally ending a relationship by ceasing communication) has only recently entered the lexicon, it is a regularly used form of relationship dissolution. However, little research has examined the emotional experiences of ghosting, particularly the experiences of those on both sides of the ghosting process. In a multi-method study, participants who had both ghosted and been ghosted in previous romantic relationships (N = 80) provided narratives of their experiences and completed questionnaires. The narrative responses were analyzed by coders and by using LIWC. Ghosters and ghostees used similar overall levels of positively and negatively valenced words to describe their experiences, but ghosters were more likely to express guilt and relief, whereas ghostees were more likely to express sadness and hurt feelings. Ghostees also experienced more of a threat to their fundamental needs - control, self-esteem, belongingness, meaningful existence - than ghosters.

Mixing Misery and Gin: The Effect of Alcohol Administration on Ostracism Response.

Williams's need-threat model proposes that ostracism responses are reflexive and, because of their evolutionary significance, difficult to diminish. Alcohol is widely consumed in social contexts and for reasons of coping with social stress, and major theories of alcohol propose that intoxication disrupts cognitive appraisal of environmental threats, leading to stress relief. Surprisingly, though, no well-powered experimental research has examined the impact of alcohol intoxication on distress from social ostracism. In three studies across two independent laboratories (N = 438), participants were randomly assigned to receive either an alcoholic or nonalcoholic (i.e., no-alcohol control or placebo) beverage and were exposed to an ostracism (or social inclusion) manipulation. Results, which emerged as remarkably consistent across all studies, indicated strong and consistent effects of ostracism on mood and needs satisfaction among both intoxicated and sober participants. Findings have important implications for ostracism theory and speak to boundary conditions for alcohol's ability to relieve stress.

I'm up here! Sexual objectification leads to feeling ostracized.

Theory and research demonstrate that women are frequently the targets of sexually objectifying behavior, viewed and treated by others as mere objects for pleasure and use. When sexually objectified, attention is principally focused on scrutinizing and valuing their physical features, whereas their internal attributes (e.g., thoughts, feelings, personhood) may be largely ignored (Bartky, 1990). Although the processes and negative effects associated with sexual objectification have been examined extensively, no work has examined the "ignoring" component of sexual objectification. We reasoned that sexually objectifying a woman by ignoring and devaluing some of her personal attributes or features is akin to partial ostracism. Although sexual objectification and partial ostracism may seem to comprise opposite characteristics (i.e., attention vs. ignoring), we posit that sexually objectifying a woman, much like partial ostracism, involves ignoring some of her internal attributes (e.g., thoughts, feelings, voice). Across 4 studies, we expected and found evidence that a sexual objectification experience (vs. control conditions) resulted in women feeling sexually objectified, which led to increased feelings of ostracism, which, in turn, threatened and lowered women's fundamental need satisfaction (i.e., belonging, control, self-esteem, and meaningful existence). Our findings suggest that not only do women suffer the adverse consequences of being sexually objectified, but when they are objectified, they can also experience the added negative effects associated with being partially ostracized, a novel finding that contributes to both the sexual objectification and ostracism literature. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Ostracism Increases Automatic Aggression: The Role of Anger and Forgiveness.

While research on the "ostracism-aggression" link has focused on controlled processes in aggression, little effort has been devoted to examining the relation between ostracism and automatic aggression. Based on theories of aggression, we found that ostracized participants reported higher levels of automatic aggression than included participants (Studies 1 and 2). Furthermore, the association between ostracism and automatic aggression was mediated by anger and was especially prominent for people low in forgiveness (as compared to people high in forgiveness; Study 3). The implications of these findings are discussed.

Ladd Wheeler (1937-2018).

Presents an obituary for Ladd Wheeler (1937-2018). Wheeler was a leading researcher in what some have called the "golden age of social psychology." To those who had the good fortune of working with him, Ladd was known for his ability to separate sense from nonsense both in psychology and in life, as a supportive collaborator and mentor, and as a tenacious grammarian. Among his numerous publications is a book, Interpersonal Influence (1970), that introduced generations of students to the core mission of social psychology-how the social environment affects behavior. Wheeler was president of the Society for Personality and Social Psychology in 1986 and founding editor of the Review of Personality and Social Psychology from 1980 to 1983. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Is inclusion a valid control for ostracism?

Considerable knowledge about ostracism's impact comes from research using Cyberball, an online ball-tossing game. In Cyberball, the inclusion condition is the control condition, to which ostracism is compared. The assumption is that Cyberball-inclusion is not affirming and represents an expected level of inclusion. However, without a no-inclusion control condition, it is unclear whether inclusion elevates need satisfaction, whether ostracism depresses need satisfaction, or both. We introduce Cybertree-a control condition designed to provide a similar experience to Cyberball without inclusion. Individuals playing Cybertree did not differ from included individuals in terms of feeling ostracized, level of need satisfaction, and mood. Both Cyberball inclusion and Cybertree differed significantly from ostracized individuals. We conclude that Cyberball inclusion is a reasonable control group for Cyberball ostracism but discuss research questions that may benefit from the use of Cybertree.

Racial (vs. self) affirmation as a protective mechanism against the effects of racial exclusion on negative affect and substance use vulnerability among black young adults.

Affirming one's racial identity may help protect against the harmful effects of racial exclusion on substance use cognitions. This study examined whether racial versus self-affirmation (vs. no affirmation) buffers against the effects of racial exclusion on substance use willingness and substance use word associations in Black young adults. It also examined anger as a potential mediator of these effects. After being included, or racially excluded by White peers, participants were assigned to a writing task: self-affirmation, racial-affirmation, or describing their sleep routine (neutral). Racial exclusion predicted greater perceived discrimination and anger. Excluded participants who engaged in racial-affirmation reported reduced perceived discrimination, anger, and fewer substance use cognitions compared to the neutral writing group. This relation between racial-affirmation and lower substance use willingness was mediated by reduced perceived discrimination and anger. Findings suggest racial-affirmation is protective against racial exclusion and, more generally, that ethnic based approaches to minority substance use prevention may have particular potential.

Hurt people hurt people: ostracism and aggression.

Because ostracism hurts, it can trigger aggression. Guided by the theoretical framework of the temporal need-threat model of ostracism, we review the existing research that investigates this ostracism-aggression link over the last two decades. Both correlational and experimental research have provided substantial support for the model's prediction that ostracism may instigate aggression. Recent research continues to investigate why this occurs, and who is most likely to become aggressive when ostracized. A new and exciting body of literature emerges, which seeks to inform interventions for coping with ostracism and for reducing ostracism-related aggression.

When Silence Is Not Golden: Why Acknowledgment Matters Even When Being Excluded.

Following ostracism, individuals are highly sensitive to social cues. Here we investigate whether and when minimal acknowledgment can improve need satisfaction following an ostracism experience. In four studies, participants were either ostracized during Cyberball (Studies 1 and 2) or through a novel apartment-application paradigm (Studies 3 and 4). To signal acknowledgment following ostracism, participants were either thrown a ball a few times at the end of the Cyberball game, or received a message that was either friendly, neutral, or hostile in the apartment-application paradigm. Both forms of acknowledgment increased need satisfaction, even when the acknowledgment was hostile (Study 4), emphasizing the beneficial effect of any kind of acknowledgment following ostracism. Reinclusion buffered threat immediately, whereas acknowledgment without reinclusion primarily aided recovery. Our results suggest that minimal acknowledgment such as a few ball throws or even an unfriendly message can reduce the sting of ostracism.

Softening the Blow of Social Exclusion: The Responsive Theory of Social Exclusion.

Social exclusion is an interactive process between multiple people, yet previous research has focused almost solely on the negative impacts on targets. What advice is there for people on the other side (i.e., sources) who want to minimize its negative impact and preserve their own reputation? To provide an impetus for research on the interactive nature of exclusion, we propose the Responsive Theory of Social Exclusion. Our theory postulates that targets and sources' needs are better maintained if sources use clear, explicit verbal communication. We propose that sources have three options: explicit rejection (clearly stating no), ostracism (ignoring), and ambiguous rejection (being unclear). Drawing on psychology, sociology, communications, and business research, we propose that when sources use explicit rejection, targets' feelings will be less hurt, their needs will be better protected, and sources will experience less backlash and emotional toil than if sources use ambiguous rejection or ostracism. Finally, we propose how the language of rejections may impact both parties.

Disagreeableness as a Cause and Consequence of Ostracism.

Ostracism's negative consequences have been widely documented, but research has yet to explore the personality characteristics of its targets that precipitate ostracism. Based on theories of the functions of ostracism, we found that people are more willing to ostracize disagreeable targets than more agreeable targets (Studies 2 and 3). This outcome was mediated by participants' interpersonal trust toward the target, and was especially strong for people who highly endorse fairness as a foundation for morality (Study 4). Ironically, the experience of ostracism induced a state of disagreeableness: the very characteristic that elicits ostracism from others (Study 5). This relationship was mediated by feelings of anger (Study 6). Findings indicate disagreeableness is a particularly negative outcome of ostracism, because it leads to further ostracism.

Ostracism and attachment orientation: Avoidants are less affected in both individualistic and collectivistic cultures.

Ostracism--being excluded and ignored--is painful and threatens needs for belonging, self-esteem, control and meaningful existence. Many studies have shown that immediate responses to ostracism tend to be resistant to moderation. Once ostracized individuals are able to reflect on the experience, however, personality and situational factors moderate recovery speed and behavioural responses. Because attachment orientation is grounded in perceptions of belonging, we hypothesized that attachment orientation would moderate both immediate and delayed reactions to laboratory-induced ostracism. Participants from individualistic or collectivistic cultures were either included or ostracized in a game of Cyberball, a virtual ball-toss game. In both cultures, we found that compared to more securely attached individuals, more avoidant participants were less distressed by ostracism, but more distressed by inclusion. It is suggested that over and beyond differences in culture, individuals who avoid meaningful attachment may be less affected by ostracism.

Ostracism in Everyday Life: The Effects of Ostracism on Those Who Ostracize.

Ostracism is a negative interpersonal experience that has been studied primarily in laboratory settings. Moreover, these studies have focused primarily on how people feel when they have been ostracized. The present study extended this research by investigating ostracism as it occurs in daily life, focusing on how people feel about ostracizing someone. Using a method modeled after the Rochester Interaction Record (RIR), for two weeks, 64 participants (adults residing in the community) described what happened each time they ostracized someone. The questions in the diary were based on Williams's (2001) need-threat model of ostracism. Most ostracism episodes were directed toward people of equal status, and participants reported lower levels of belonging but higher levels of control after ostracizing someone. Punitive ostracism was associated with more positive outcomes for the source than when people ostracized someone for other reasons.

The Role of Burden and Deviation in Ostracizing Others.

Ostracism (being excluded and ignored) is a painful experience, so why do individuals ostracize others? Previous research suggests individuals often ostracize those who are deviate, but not always. We posit that there may be two types of deviation, burdensome and non-burdensome, and the former is most likely to be ostracized. Study 1 manipulated burdensome deviation by programming a group member to perform more slowly (8 or 16 sec.) than others (4 sec.) in a virtual ball-toss game. Participants perceived slower players as more burdensome and deviate than normal speed players. Additionally, participants ostracized (gave fewer ball tosses to) the slowest player. Study 2 examined participant responses to both burdensome deviation (8- and 16-sec. players) and non-burdensome deviation (goth appearance). Participants again perceived the slower players to be burdensome and deviate, and ostracized them. They perceived the goth player to be deviate but not burdensome and did not ostracize this player.

Why Social Pain Can Live on: Different Neural Mechanisms Are Associated with Reliving Social and Physical Pain.

Although social and physical pain recruit overlapping neural activity in regions associated with the affective component of pain, the two pains can diverge in their phenomenology. Most notably, feelings of social pain can be re-experienced or "relived," even when the painful episode has long passed, whereas feelings of physical pain cannot be easily relived once the painful episode subsides. Here, we observed that reliving social (vs. physical) pain led to greater self-reported re-experienced pain and greater activity in affective pain regions (dorsal anterior cingulate cortex and anterior insula). Moreover, the degree of relived pain correlated positively with affective pain system activity. In contrast, reliving physical (vs. social) pain led to greater activity in the sensory-discriminative pain system (primary and secondary somatosensory cortex and posterior insula), which did not correlate with relived pain. Preferential engagement of these different pain mechanisms may reflect the use of different top-down neurocognitive pathways to elicit the pain. Social pain reliving recruited dorsomedial prefrontal cortex, often associated with mental state processing, which functionally correlated with affective pain system responses. In contrast, physical pain reliving recruited inferior frontal gyrus, known to be involved in body state processing, which functionally correlated with activation in the sensory pain system. These results update the physical-social pain overlap hypothesis: while overlapping mechanisms support live social and physical pain, distinct mechanisms guide internally-generated pain.

The ordinal effects of ostracism: a meta-analysis of 120 Cyberball studies.

We examined 120 Cyberball studies (N = 11,869) to determine the effect size of ostracism and conditions under which the effect may be reversed, eliminated, or small. Our analyses showed that (1) the average ostracism effect is large (d > |1.4|) and (2) generalizes across structural aspects (number of players, ostracism duration, number of tosses, type of needs scale), sampling aspects (gender, age, country), and types of dependent measure (interpersonal, intrapersonal, fundamental needs). Further, we test Williams's (2009) proposition that the immediate impact of ostracism is resistant to moderation, but that moderation is more likely to be observed in delayed measures. Our findings suggest that (3) both first and last measures are susceptible to moderation and (4) time passed since being ostracized does not predict effect sizes of the last measure. Thus, support for this proposition is tenuous and we suggest modifications to the temporal need-threat model of ostracism.