[Effect of the complex treatment conducted in the rehabilitation center in the city of Loznitsa on oral glucose tolerance and insulin secretion in patients with morbid obesity]. / Vliianie na kompleksnoto lechenie, provezhdano v rekhabilitatsionniia tsentur v gr. Loznitsa, vUrkhu oralniia gliukozen tolerans i insulinovata sekretsiia pri patsienti s visokostepenno zatlustiavane.

In the rehabilitation center Loznitsa the influence of the comprehensive treatment on the oral glucose tolerance test and insulin secretion was studied in patients with high-degree obesity. A flat blood sugar and insulin curve by oral glucose tolerance test was found without manifested hyperglycemia and hyperinsulinemia. One month treatment leads to a decrease of the basal insulinemia on the background of which the stimulating effect of glucose loading is more clearly expressed up to the 120th minute but without increase of the absolute values above the reference ranges.

Biopharmaceutical investigation of rectal suppositories. Part 2(1): Pharmaceutical and biological availability of phenobarbital and phenobarbital-sodium.

The influence of the suppository base and drug solubility on the release an absorption of phenobarbital and phenobarbital-sodium from model suppositories was investigated. It was established that the pharmaceutical and biological availability of phenobarbital is higher from a hydrophilic base because of its improved solubility. The rate and the degree of release of phenobarbital-sodium are more significant from lipophilic bases. The bioavailability of two drug forms-phenobarbital and phenobarbital-sodium--is almost equal after rectal and oral administration.

Biopharmaceutical investigations of rectal suppositories. Part 1: Pharmaceutical and biological availability of theophylline.

The influence of suppository base and some tensides on the release and resorption of theophylline from model rectal suppositories was investigated in a preliminary way. It was established that the original Bulgarian suppository base Novosup ensures higher pharmaceutical and biological availability of theophylline in comparison with other investigated lipophilic bases. The preliminary inclusion of Tween 80 in Witepsol H 15 increased the pharmaceutical and biological availability of the drug. A linear relationship between the pharmaceutical and biological availability was observed after administration of model suppositories in rabbits.