ABSTRACT
An 84-year-old black woman had a right caruncular lesion that had progressively enlarged over the past 3 months. Surgical excision and cryotherapy were performed. A biopsy confirmed the diagnosis of caruncular malignant melanoma, a rare lesion which, to our knowledge, has not been previously reported in a black patient.
Subject(s)
Black People , Conjunctival Neoplasms/pathology , Eyelid Neoplasms/pathology , Melanoma/pathology , Aged , Aged, 80 and over , Antigens, Neoplasm/analysis , Conjunctival Neoplasms/chemistry , Conjunctival Neoplasms/ethnology , Conjunctival Neoplasms/surgery , Cryosurgery , Eyelid Neoplasms/chemistry , Eyelid Neoplasms/ethnology , Eyelid Neoplasms/surgery , Female , Humans , Immunohistochemistry , Keratins/analysis , Melanoma/chemistry , Melanoma/ethnology , Melanoma/surgery , Melanoma-Specific Antigens , Neoplasm Proteins/analysis , S100 Proteins/analysisABSTRACT
We present an unusual case of Langerhans cell histiocytosis (LCH) involving the thyroid gland initially diagnosed by fine needle aspiration biopsy in a 16-year-old boy. The cytologic findings in LCH involving the thyroid include high cellularity, isolated Langerhans cells with prominent nuclear grooves, multinucleate Langerhans cells, eosinophils, lymphocytes and rare benign follicular cells. Confirmation of LCH was obtained by core biopsy, positive S-100 protein immunohistochemical staining and the demonstration of Birbeck granules on electron microscopy. We present the complete clinicopathologic features of this case with a review of the literature and discussion of the differential diagnosis.
