ABSTRACT
The long-acting antiphlogistics tenoxicam (Ro 12-0068, Tilcotil) and piroxicam in single daily oral doses of 20 mg are compared in a double-blind, group-comparative, randomised trial planned to last for five years. Results of 12 months' treatment of 108 patients with osteoarthritis of the hip or knee have been reported. This interim analysis focuses mainly on the 12 to 24 month interval. The clinical improvements obtained within the first 12 months persisted during the second year in the 55 patients remaining on treatment. After 24 months, 53 patients had been withdrawn prematurely, three-quarters because of inefficacy or intolerance. Only six patients were withdrawn between 12 and 24 months, three for lack of efficacy, two for side-effects and one for reasons unrelated to therapy. There was no difference between the treatment groups with regard to incidence, time or reason for withdrawal, and only small, insignificant differences in efficacy and tolerability. This trial shows that long-term treatment of osteoarthritis with tenoxicam and with piroxicam is beneficial. Once efficacy and tolerability have been established, maintenance of therapy is feasible.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Hip Joint , Knee Joint , Osteoarthritis/drug therapy , Piroxicam/analogs & derivatives , Piroxicam/therapeutic use , Activities of Daily Living , Adult , Aged , Aged, 80 and over , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Clinical Trials as Topic , Double-Blind Method , Female , Humans , Male , Middle Aged , Piroxicam/adverse effects , Random Allocation , Time FactorsABSTRACT
Diclophenac sodium, Voltaren, has been tested against indomethacin and placebo in a four-week double-blind between-patient trial in 182 patients with rheumatoid arhritis. The ameliorating effect of Voltaren on the usual clinical parameters was comparable to that of indomethacin, while no significant changes were observed in the placebo group. Side effects during treatment with Voltaren and indomethacin appeared mainly form the gastrointestinal tract and from CNS. While side effects from the gastrointestinal tract were similar in the two groups, side effects from the CNS appeared significantly less frequent during treatment with Voltaren than during treatment with indomethacin. No skin reactions, diarrhoea or gastrointestinal bleeding were observed in either group. Long-term studies are needed to establish the place of Voltaren in the treatment of rheumatoid arthritis.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Arthritis, Rheumatoid/drug therapy , Indomethacin/therapeutic use , Phenylacetates/therapeutic use , Adult , Aged , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Clinical Trials as Topic , Female , Humans , Male , Middle Aged , Phenylacetates/adverse effectsABSTRACT
In a double-blind cross-over trial the clinical efficacy of ketoprofen (19.583 R.P., Orudis, Profenid N.D.), in comparison with that of indomethacin was investigated in 30 patients with rheumatoid arthritis. The two drugs were each given in a dosage of 150 mg daily for a period of 14 days. The clinical effects of ketoprofen and indomethacin were equal (p less than 0.90), but several side-effects appeared less often and to a milder degree during ketoprofen treatment. The study indicates that ketoprofen may prove to be a valuable drug in the treatment of rheumatoid arthritis.
Subject(s)
Analgesics/therapeutic use , Arthritis, Rheumatoid/drug therapy , Benzophenones/therapeutic use , Ketoprofen/therapeutic use , Adult , Aged , Analgesics/administration & dosage , Analgesics/adverse effects , Clinical Trials as Topic , Drug Evaluation , Female , Gastrointestinal Diseases/chemically induced , Headache/chemically induced , Humans , Indomethacin/administration & dosage , Indomethacin/adverse effects , Indomethacin/therapeutic use , Ketoprofen/administration & dosage , Ketoprofen/adverse effects , Male , Middle Aged , Time FactorsABSTRACT
In a double-blind cross-over trial, ketoprofen was found to be as effective as indomethacin in the treatment of rheumatoid arthritis. Side-effects, particularly headache and vertigo, were less common in patients receiving ketoprofen.
