[The differences in the estimation of depression severity by psychiatrists and patients during the combined treatment with agomelatine (a multicenter study "EMOTSIA")]. / Razlichiya v otsenke tyazhesti depressii vrachami i patsientami v protsesse kombinirovannoi terapii agomelatinom (mul'titsentrovoe issledovanie «EMOTsIYa¼).

AIM: To compare the prognosis of depression severity estimated by the physician and by the patient based on the treatment outcome. MATERIAL AND METHODS: One hundred and seven patients with depression were examined. Mental status was assessed with HАМ-D, SHAPS, CGI-S, CGI-I, PGI-S, PGI-I and VAS. A data analysis was performed. RESULTS: There were differences in the estimation of depression severity by psychiatrists and patients. Moreover, the scores on HАМ-D and CGI-S were not consistent when assessed by psychiatrists. As the severity of depression decreased and patient's state improved during the treatment with agomelatine (valdoxan), the assessments of the changes by the psychiatrist and the patient became similar. CONCLUSION: Agomelatine (valdoxan) is effective and tolerable in the treatment of depression of any severity. The differences between the psychiatrist's and patient's estimation of the depression severity at baseline using different psychometric scales can level the prognostic value of treatment outcome.

[Mental disorders in a pediatric clinic]. / Psikhicheskie rasstroistva v pediatricheskoi klinike.

In general pediatric clinic 262 children aged 1-15 years with functional hyperthermia, functional disorders of cardiac rhythm (extrasystole, paroxysmal and recurrent tachycardia), arterial hyper- and hypotension, autonomic dysfunctions were examined. 21 children with organic cardiac diseases were examined too. Mental disorders were revealed in all the cases: mono- and bipolar affective disorders (58.1%) as well as affective-dilutional (10.4%) states, primarily in the form of "masked" hypomanias, neurotic and neurotic-like (16.2%), psychopathic and psychopathic-like (7.0%), psychoorganic (3.7%) and epileptiform (4.6%) syndromes. The spectrum of mental disorders was extremely wide--from practical normal (in limits of reactions of personal accentuations or age crisis) to endogenic diseases. Combined treatment including drug therapy, psychotherapy and family correction was quite effective.

[Psycho-autonomic correlations in neurocirculatory asthenia in young age]. / Psikhovegetativnye sootnosheniia pri vegetososudistoi distonii v iunosheskom vozraste.

As many as 91 patients aged 17-25 years seen at the students' outpatient hospital for autonomic disorders, namely for vegetovascular dystonia (VVD) were examined. The data of somatovegetative and psychiatric examinations were compared. It has been shown that the symptomatic diagnosis of VVD may mask both vegetative lability common to the mentally normal and practically healthy subjects and vegetative dystonia syndrome proper, which is a component of psychovegetative syndromes. The statistically significant diagnostic somatovegetative and electrophysiological signs were distinguished, which make it possible to supposedly distribute groups with psychopathological syndromes and mentally healthy subjects.

[Clinico-psychopathologic and somato-autonomic studies of functional hyperthermia in adolescents]. / Kliniko-psikhopatologicheskoe i somatovegetativnoe issledovanie funktsional'nykh gipertermii u podrostkov.

In a non-psychiatric clinic a combined psychiatric and somato-autonomic investigation was performed in 75 prepuberty and puberty children with functional hyperthermia . Syndromal and nosological characterization was performed on a spectrum of psychic disorders in these patients. Some correlations were found between syndromal and nosological distributions and grouping based on somato-autonomic++ picture.

[The effect of the earthquake in Armenia on the mental health of the pediatric population of the damaged regions]. / Vliianie zemletriaseniia v Armenii na psikhicheskoe zdorov'e detskogo naseleniia postradavshikh raionov.

The authors relate neuropsychic disorders in children and adolescents of Armenia in the acute period and 3 months after the earthquake. The pathological disorders were dependent on the individual reactivity of the child and environmental factors. 3 months after the earthquake 31% of the examines demonstrated marked mental disturbances. The prevalence of mental pathology among the population groups living in the regions damaged by the earthquake demands organization of specialized assistance for the population.

[Autonomic vascular asthenia as a component of the psycho- autonomic syndrome in slowly progressing schizophrenia and cyclothymic disorder in young patients]. / Vegetososudistaia distoniia kak komponent psikhovegetativnogo sidroma pri maloprogredientnoi shizofrenii i tsiklotimii u bo'lnykh iunosheskogo vozrasta.

Investigated were 55 patients with slow-progredient schizophrenia and cyclothymia aged 17 to 25 with the syndrome of vaso-autonomic dystonia (VAD) accompanying their mental disorder. VAD was found in 80% of the depressive cases, hypomaniac syndromes and psychopath-like (residual) states. Each of these disorders correlated with a distinct type of VAD. In a majority of the cases VAD manifested after several years of mental disease. The study provides grounds for combined psychotropic and rational psychotherapy with an early social rehabilitating assistance. The study substantiated the necessity of psychiatric services aimed at specialized psychiatric aid to these patients in the general out-patient clinic network.

[Psychoautonomic syndrome in non-infectious subfebrile conditions in children]. / Psikhovegetativnyi sindrom pri neinfektsionnykh subfebrilitetakh u detei.

To ascertain the cerebral organization and the importance of its specific levels in the occurrence of the thermopathological syndrome associated with vegetovascular dystonia, 40 children aged 8-15 years with non-infectious subfebrile conditions of long standing were examined. The children's status was marked by polysystemic shifts common to the neurogenous disorders. Of crucial significance was dysfunction of the structures of the suprasegmental level (the limbic-reticular complex) of vegetative regulation with the involvement of the specialized hypothalamic centers of thermoregulation, with excessive sympathetic influences at the periphery and formation of the psychovegetative syndrome. An individual analysis of the psychovegetative syndrome makes it possible to define the contribution of the concrete endo- and exogenous factors to the pathogenesis of non-infectious subfebrile conditions and to develop a differential approach to the treatment.