ABSTRACT
The article presents results of studying alterations of biochemical indices of blood serum in 47 patients of both genders with multiple fractures of bones of lower extremities occurred in period up to 5 days after trauma. All examined patients were allocated in 5 groups: group I (n=10, average age 41±9 years) - patients received during 24 hours after trauma; group II (n=10, average age 42±7 years) - patients received during 24-48 hours after trauma; group III (n=10, average age 42±6 years) - patients received after 72-96 hours after trauma; group IV (n=8, average age 43±6years) - patients received 72-96 hours after trauma; group V (n=9 average age 39±8 years) - patients received after 96-120 hours after trauma. It is established that in examined patients the higher level of lactate (rate 0.745) and increased activity of aspartate aminotransferase (rate 0.553) are established most often. The high rate of increasing of activity of creatinine phosphatase was marked. The reliable correlation dependence on treatment period had three indices: total creatinine kinase, r=-0.534 (p=0.03); total protein, r=-0.477 (p=0.02) and lactate, r=0.406 (p=0.04). It was established also that average periods of treatment of received patients with both increased activity of total creatine kinase and level of lactate or decreased level of total protein, were reliably higher than average periods of treatment of patients with normal indices at the moment of reception into hospital. These three indices can be included into listing of tests for evaluation of trauma severity in patients with multiple fractures of bones of lower extremities with possibility of application of these tests as additional criteria of monitoring under management of patients in post-traumatic period.