ABSTRACT
Modulating effects of some drugs and HBO on adaptation reaction have been studied in 74 surgical patients. Investigation methods included cardiac rhythm record (statistical analysis with histogram plotting--sympathetic activity index), tcpO2, tcpCO2, SaO2, finger pulse amplitude (vasomotor tone evaluation), and evaluation of changes in arterial pressure and heart rate. The treatment included intravenous propranolol (0.92-1.38 micrograms/kg/min) or cordanum (1.85-2.7 micrograms/kg/min) or clonidine (0.018-0.037 microgram/kg/min) or dalargin (0.55-0.83 microgram/kg/min) HBO-100% O2 for 1 h at 1.5 ATA during increase of sympathetic activity. The results indicate that all drugs and HBO modulate the adaptation response of the organism and improve the outcomes of surgery.
Subject(s)
Hyperbaric Oxygenation , Nervous System/drug effects , Perioperative Care/methods , Stress, Physiological/prevention & control , Adaptation, Physiological/drug effects , Algorithms , Female , Hemodynamics/drug effects , Humans , Hyperbaric Oxygenation/statistics & numerical data , Male , Middle Aged , Perioperative Care/statistics & numerical data , Time FactorsSubject(s)
Diagnosis, Computer-Assisted/methods , Electrocardiography/methods , Heart Rate/physiology , Autonomic Nervous System/drug effects , Autonomic Nervous System/physiopathology , Cardiovascular Diseases/diagnosis , Cardiovascular Diseases/physiopathology , Diabetic Angiopathies/diagnosis , Diabetic Angiopathies/physiopathology , Diagnosis, Computer-Assisted/statistics & numerical data , Electrocardiography/drug effects , Electrocardiography/statistics & numerical data , Heart Rate/drug effects , Humans , Signal Processing, Computer-AssistedABSTRACT
A variant of total anesthesia with modified doses of ketamine was developed and tried in 1305 patients in an outpatient setting. Low doses of ketamine hydrochloride (initial dose 25-70 mg, repeated one 20-40 mg) do not lead to hemodynamic shifts, disorders of spontaneous respiration, and long postanesthetic depression. At the same time the level of anesthesia and analgesia attained is sufficient for complete sanitization of the oral cavity. The suggested method extends the indications to total anesthesia in stomatological interventions on an outpatient basis, is simple for anesthesiologist, and safe for the patients.
Subject(s)
Anesthesia, Dental/methods , Anesthesia, General/methods , Anesthesia, Intravenous/methods , Dental Care/methods , Ketamine/administration & dosage , Adolescent , Adult , Child , Dental Restoration, Permanent , Female , Humans , Male , Middle Aged , Preanesthetic Medication , Tooth ExtractionABSTRACT
The authors discuss the mechanisms of compensatory reactions of the human vegetative nervous system, its central and peripheral parts, in breathing a gaseous hypoxic mixture. Five types of neurovegetative reactions of the organism aimed at maintaining the oxygen balance in blood were distinguished. The interrelationship of values reflecting the activity of the central and peripheral parts of the vegetative nervous system in exposure to emergency effects is discussed.
Subject(s)
Autonomic Nervous System/physiology , Hypoxia/physiopathology , Oxygen/blood , Adolescent , Adult , Aged , Female , Humans , Hypoxia/blood , Male , Middle AgedABSTRACT
Responses of the autonomic nervous system, its central and peripheral parts, in the human organism exposed to a hypoxic gas mixture were studied to reveal the relationship between the parameters indicative of the activity of the central and peripheral parts of the autonomic nervous system in loading tests. The different autonomic responses of the organism to stress were of high prognostic value since they allowed for a preoperative assessment of surgical risks in surgical patients.
Subject(s)
Autonomic Nervous System/physiopathology , Hypoxia/physiopathology , Stress, Physiological/physiopathology , Adult , Aged , Female , Humans , Hypoxia/complications , Male , Middle Aged , Prognosis , Stress, Physiological/etiologyABSTRACT
The paper is concerned with the data on change in the blood level of ACTH, STH, TSH, cortisol, T3, insulin, C-peptide during a 25-minute session of respiration using a gaseous hypoxic mixture with 10% oxygen (GHM-10). The investigation was performed in 23 healthy volunteers. Change in the hormonal status, characteristic of a moderate stress-reaction, was observed in 60% of the examinees. It was found out that during a GHM-10 session a degree of change in function of the studied factors of the endocrine system showed correlation with change in the activity of the autonomic nervous system.
