[A diagnostic analysis of a genetic mutation associated with a deficiency of leukocyte adhesion in cattle]. / Diagnosticheskii analiz geneticheskoi mutatsii, assotsiirovannoi s defitsitom adgezivnosti leikotsitov u krupnogo rogatogo skota.

Bovine leukocyte adhesion (BLAD) is a recessive autosomal disease in Holstein-Friesian cattle caused by point mutation in CD18 gene encoding neutrophil-surface glycoprotein. To determine BLAD carriers, the convenient primers were chosen to amplify the mutant region of gene with the following restriction analysis. A screening program for BLAD has been initiated. Among 190 animals from different Ukrainian farms 6 were heterozygous according to the tested trait, i.e., BLAD deficient. No homozygous BLAD carriers were detected.