ABSTRACT
Lyophilized vaccines prepared according to the method of Käber, modified by Achmarine, are utilized in the Soviet Union for the immunization of mink against botulin of the type C-alpha. These vaccines can be conserved more than a year at laboratory temperature without losing their efficacity. A Table allows a rapid and accurate determination of the quantity of vaccine to be injected into the mink to provide the same efficacity as a dose of standard vaccine.
Subject(s)
Bacterial Vaccines/standards , Botulism/veterinary , Clostridium botulinum/immunology , Mink , Animals , Bacterial Vaccines/administration & dosage , Botulism/immunology , Methods , MiceABSTRACT
Description of the preparation and composition of a new type of polyvalent vaccine against bradsot, infectious enterotoxemia and malignant edema (necrotic hepatitis) of sheep as well as dysentery of lambs. This vaccine is a formolized polyanatoxin obtained after centrifugation, purification and concentration of the toxins followed by formolization and adsorption on aluminum hydroxyde. The serum antibody titers are much higher than after utilizing the usual vaccines and the period of immunity in the sheep is considerably extended.