Subject(s)
Graves Disease/complications , Graves Disease/diagnostic imaging , Thymus Hyperplasia/diagnostic imaging , Thymus Hyperplasia/etiology , Adult , Graves Disease/radiotherapy , Humans , Iodine Radioisotopes , Male , Mediastinal Neoplasms/diagnostic imaging , Thymus Hyperplasia/pathology , Tomography, X-Ray ComputedABSTRACT
In nine female medical students we found an increase of 20 percent in mean cholesterol level during an important examination. A decrease in thyroxine was found but there was no correlation with cholesterol changes.
Subject(s)
Cholesterol/blood , Stress, Psychological/blood , Thyroxine/blood , Adult , Female , HumansABSTRACT
High values for the free thyroxine fraction were found in the serum of 24 patients during the early phase of myocardial infarction. A strong correlation between the free thyroxine fraction and free fatty acids suggests that they compete for protein binding sites. The increase in free thyroxine may have undesirable effects on myocardial oxygen demand during acute myocardial infarction.
Subject(s)
Myocardial Infarction/blood , Thyroxine/blood , Adult , Aged , Fatty Acids, Nonesterified/blood , Humans , Kinetics , Male , Middle AgedABSTRACT
Total cholesterol, phospholipids, and triglycerides in serum were studied during myocardial infarction in a patient group treated with glucose, insulin and potassium (GIK), and a conventionally treated group. There was no difference in the typical changes of cholesterol and phospholipids between the groups, but the GIK-treated group had a late rise in triglycerides.
Subject(s)
Cholesterol/blood , Glucose/therapeutic use , Insulin/therapeutic use , Myocardial Infarction/drug therapy , Phospholipids/blood , Potassium/therapeutic use , Triglycerides/analysis , Clinical Trials as Topic , Double-Blind Method , Humans , Myocardial Infarction/bloodABSTRACT
Serum lipids and thyroxine were determined in 26 men participating in a 90-km cross-country ski race, before, immediately after, and on the following days. Serum cholesterol was unchanged immediately after the race, but then fell significantly and remained low during the observation period. During the race the fatty acid composition of serum free fatty acids changed towards the composition of ordinary adipose tissue. The compostiion of serum triglycerides showed similar but less pronouced changes. On the following days an increase in the arachidonic, and a decrease in the linoleic acid fraction of the total serum lipids were observed. Total thyroxine and free thyroxine in serum were significantly increased at the end of the race, but had returned to the pre-raced levels during the rest of the observation period. The observations correspond to the findings during acute, severe illness, and are compatible with the hypothesis that some of the changes in serum lipids following severe somatic stress are due to increased thyroid hormone activity.
