Subject(s)
Renal Dialysis , Adult , Aged , Dialysis , Evaluation Studies as Topic , Female , Humans , Inulin/metabolism , Male , Metabolic Clearance Rate , Middle Aged , Permeability , Polymethacrylic Acids , Time Factors , UltrafiltrationABSTRACT
A high flux artificial kidney system, which permits control over ultrafiltration, has been developed and patients are now being treated with it at a large outpatient kidney center. The basic operating characteristics have been described and some preliminary clinical results mentioned. Characteristics of the Hospital Artificial Kidney System are: 1. Higher clearances for middle molecules than conventional systems; 2. Adequate clearances for small solutes such as urea; 3. Predictable control of ultrafiltration with discrepancies between actual weight loss and theoretical weight loss on the order of 0.7 to 1.3 ml/min, when the system is operated in the designated manner.
Subject(s)
Kidneys, Artificial , Evaluation Studies as Topic , Humans , Membranes, Artificial , Metabolic Clearance Rate , Molecular Weight , Permeability , UltrafiltrationABSTRACT
A system which permits high rates of middle molecule removal while preserving the removal of low molecular weight substances is described. It consists of a high fluid flux hollow fiber artificial kidney and an ultrafiltration controller. When used in combination, high rates of convective transport can be achieved through rapid ultrafiltration and reconstitution of blood with physiologic salt solutions. The theoretical impact of changing from conventional dialysis to this form of therapy on the body burden of middle molecules is estimated.
