ABSTRACT
The aim of present study was an investigation of effective of product from ceolites which is suggested as biologically active food additive. The high-calorie, high-fat, high-cholesterol diet was developed. The rats (female and male) were fed with the biologically active food additive during 1 month at dose 70 mg per kg of body weight. Their blood and liver were investigated to measure total lipids, total cholesterols, phospholipid, triglycerides. Morphologic parameters of liver was studied. Cholesterol lowering effect of biologically active food additive in rat (female) has been shown.
Subject(s)
Anticholesteremic Agents , Food Additives , Zeolites/pharmacology , Animals , Cholesterol/blood , Female , Lipids/blood , Liver/drug effects , Liver/metabolism , Male , Rats , Rats, Wistar , Sex Factors , Time Factors , Zeolites/administration & dosageABSTRACT
The aim of present study was an investigations of safety of product "Bioton-1" which is suggested as biologically active food additive. Long-term intake the product "Bioton-1" by the rats Wistar during 6 month at doses of 0.75 ml per kg of body weight hadn't an unfavorable effects on integral, biochemical, hemotologic and morphologic parameters of animals. It was shown on two generations of rats that "Bioton-1" hadn't an embryotoxic, gonadotoxic and teratogenic effects and also hadn't negative effect on growth and development of posterity of rats. Including into the diet of rats product "Bioton-1" at dose of 0.25 per kg of body weight during the whole life hadn't an effect on animals life duration.
Subject(s)
Panax , Plants, Medicinal , Animals , Embryo, Mammalian/drug effects , Immunoglobulins/analysis , Leukocytes/drug effects , Liver/drug effects , Male , Mutagenicity Tests , Panax/adverse effects , Plant Extracts/toxicity , Plant Roots , Rats , Rats, Wistar , Safety , Time Factors , Toxicity TestsABSTRACT
The data on safety investigation of product "Rialam", which is proposed as biologically active food supplement are presented. Chronic experiment and single generation experiment were made on Wistar rats. It is shown that diet "Rialam" in dose 100 mg/kg of body weight didn't influence negatively on growth and development of rats blood parameters, immune status, internal organs morphology, metabolism, hadn't embryotoxic, gonadotoxic and teratogenic action.
Subject(s)
Dietary Supplements/adverse effects , Amino Acids/analysis , Animals , Body Weight/drug effects , Dose-Response Relationship, Drug , Hematologic Tests , Immunity/drug effects , Minerals/analysis , Rats , Rats, WistarABSTRACT
The results of toxicological evaluation of 'concentrate bardjanoj liquid' (CBL) a new fodder additive are presented. It was shown on one generation of rats that CBL at dose of 1 g and 10 g per 1 kg of body mass had no an embryotoxic, gonadotoxic and teratogenic effects. However long-term intake of CBL during 5 month with diet of rats caused the changes in rat body. It was found increasing of relative weights of kidney, spleen and heart, decreasing of contents of total lipids, phospholipids and cholesterol in rat liver. Also the desquamative enteritis in some cases with ulcers was found. These data did not allow to recommend CBL as fodder additive in studied doses.
