ABSTRACT
The article analyzes properties of potassium and magnesium, which may exert vasodilatory, anti-inflammatory, anti-ischemic, antiaggregant, and antiarrhythmic effects. These are extremely important microelements and potentially beneficial therapeutic agents for treatment of cardiovascular diseases.
Subject(s)
Magnesium Deficiency , Anti-Arrhythmia Agents , Cardiovascular Diseases , Humans , Magnesium , PotassiumABSTRACT
The rate of acetylation of xenobiotics affects the course and prognosis of infectious diseases. The efficacy of antibiotic therapy of community-acquired pneumonia in RA-patients is lower than that in LA-ones. In order to ensure the best antimicrobial effect on the onset of the disease it is required to use regimens with the maximum permissible dose of antibacterial drugs in the regions where the rapid type prevails.
Subject(s)
Anti-Bacterial Agents/pharmacokinetics , Community-Acquired Infections/drug therapy , Community-Acquired Infections/metabolism , Isoniazid/pharmacokinetics , Pneumonia, Bacterial/drug therapy , Pneumonia, Bacterial/metabolism , Acetylation , Adult , Anti-Bacterial Agents/therapeutic use , Humans , Isoniazid/therapeutic useABSTRACT
We determined the content and binding capacity of progesterone receptors in the endometrium of patients with adenomatous and fibroid polyps, adenocystic hyperplasia, and atypical hyperplasia before and after gestagen therapy. Hyperplasia of the endometrium was accompanied by changes in affinity of cytosolic progesterone receptors for antigestagens, which provides the possibility of individual correction of hormone therapy.
Subject(s)
Endometrial Hyperplasia/metabolism , Estrogen Receptor Modulators/metabolism , Receptors, Progesterone/metabolism , 17 alpha-Hydroxyprogesterone Caproate , Adult , Endometrial Hyperplasia/drug therapy , Endometrial Hyperplasia/pathology , Estrogen Receptor Modulators/therapeutic use , Female , Humans , Hydroxyprogesterones/therapeutic use , In Vitro Techniques , Kinetics , Middle Aged , Receptors, Progesterone/drug effectsABSTRACT
Antiprogestin activity of 5H-progesterone metabolites and their analogues 16alpha,17alpha-cyclohexan-5H-pregnan-3,20-diones was tested on rats. Modified pregnancy interruption test showed that 5alpha (H)-isomers of natural and synthetic hormones exhibit maximum activity.
Subject(s)
Abortifacient Agents, Steroidal/pharmacology , Pregnancy Maintenance/drug effects , Pregnancy, Animal , Pregnanolone/pharmacology , Progesterone/metabolism , Progestins/antagonists & inhibitors , Abortifacient Agents, Steroidal/chemistry , Animals , Female , Mifepristone/pharmacology , Molecular Structure , Pregnancy , Pregnanolone/analogs & derivatives , Pregnanolone/chemistry , RatsABSTRACT
The effect of phencarol, ranitidine, propranolol, atropine, and diethylstilbestrol (known as modulators of the tamoxifen-binding sites in plasma membranes) on the 3H-tamoxifen binding to the plasma membrane fraction of white rat uterine cells was studied by determining the amounts of estradiol and H1- and H2-receptors. The interaction of tamoxifen with various receptors of uterine cells may be significant for evaluation of the tumor activity of this compound.
Subject(s)
Antineoplastic Agents, Hormonal/pharmacokinetics , Tamoxifen/pharmacokinetics , Uterus/metabolism , Animals , Cell Membrane/drug effects , Cell Membrane/metabolism , Drug Interactions , Female , Ligands , Rats , Receptors, Estradiol/drug effects , Receptors, Estradiol/metabolism , Statistics, Nonparametric , Tritium , Uterus/drug effectsABSTRACT
The investigation involved 22 reproductive and menopausal women (aged 30-48) with atypical endometrial hyperplasia. In addition to general clinical examination, all the patients underwent ultrasound scanning of the organs of the small pelvis, hysteroscopy and diagnostic curettage for morphological examination both before and after treatment. All tissue samples taken before and after treatment were assayed for cytoplasmic and plasma-membrane receptor levels and a number of biochemical parameters of plasma membranes. Hormone therapy with prolonged-release gestagen-based drugs pointed to changes which occurred in: (1) sex steroid reception at cytosol and plasma-membrane levels; (2) the lipids profile of plasma membranes, and (3) activity of membrane-related enzymes. Among the beneficial results of gestagen treatment was coming most of lipid profile parameters and plasma-membrane enzymes back to normal. However, a decrease in the progesterone reception level in target tissue after 3-6 month treatment may suggest a likelihood of development of tolerance to gestagen. The data also suggest that further research continue in this area of endometrial precancer.
Subject(s)
Endometrial Hyperplasia/diagnosis , Endometrial Hyperplasia/drug therapy , Endometrial Neoplasms/prevention & control , Progestins/therapeutic use , Adult , Cell Membrane/metabolism , Cytosol/metabolism , Drug Tolerance , Endometrial Hyperplasia/blood , Endometrial Hyperplasia/pathology , Female , Humans , Lipid Metabolism , Middle Aged , Receptors, Progesterone/metabolism , Treatment OutcomeABSTRACT
The authors studied the effect of synthetic gestagens on spontaneous contractility of the myometrium in pregnant rats. The direction of the effect of progesterone and its analogs on the contractility is determined by stereochemistry of the linkage of rings A and B of the steroid molecule. Compounds possessing translinkage (5 beta-steroids) increase the amplitude of myometrium contraction, whereas their analogs with cms-coupling of rings A and B (5 alpha-steroids), and 4,5-unsaturated steroids reduce it.
