Middle Meningeal Artery Embolization versus Surgery in Patients with Chronic Subdural Hematoma-No More Fence Sitting?

BACKGROUND: Endovascular treatment of patients with chronic subdural hematoma using middle meningeal artery (MMA) embolization could become an alternative to surgical hematoma evacuation. The aim of the study was to compare methods and identify parameters to help determine the correct treatment modality. METHODS: We retrospectively reviewed 142 cases conducted internally; 78 were treated surgically and 64 were treated using MMA embolization. We analyzed the treatment failure rate and complications, and using a binary logistic regression model, we identified treatment failure risk factors. RESULTS: We found a comparable treatment failure rate of 23.1% for the surgery group and 21.9% for the MMA embolization group. However, in the MMA embolization group, 11 cases showed treatment failure due to early neurological worsening with a need for concomitant surgery. We also found a recurrence of hematoma in 15.4% of cases in the surgery group and 6.3% of cases in the MMA embolization group. CONCLUSION: Both modalities have their advantages; however, correct identification is crucial for treatment success. According to our findings, hematomas with a maximal width of <18 mm, a midline shift of <5 mm, and no acute or subacute (hyperdense) hematoma could be treated with MMA embolization. Hematomas with a maximal width of >18 mm, a midline shift of >5 mm, and no membranous segmentation could have better outcomes after surgical treatment.

RISKGATE y operaciones en minas de carbón en Australia / RISKGATE and Australian coal operations

El principal programa de investigación de la Asociación de Carbón en Australia (ACARP), RISKGATE ha completado tres años de conocimiento en la captura y el desarrollo del sistema. El cuerpo de conocimiento del manejo de riesgos de neumáticos, colisiones, incendios, aislamiento, estratos de suelo en las minas subterráneas, suelo en minas de cielo abierto, explosiones, explosivos en minas subterráneas, explosivos en minas de cielo abierto, trabajos manuales, resbalones/tropiezos/caídas fue lanzada en diciembre del 2012. Recientemente, el proyecto a adicionado al cuerpo de conocimiento temas relacionados a escapes de gas espontaneo, fallas en la extracción de carbón, interface entre la interacción máquina-humano, depósito de escoria, higiene ocupacional y escape de cuerpos de agua a los originales 11 tópicos. En el 2014, los planes del proyecto (pendiente a la aprobación a la fundación de ACARP) es al enfoque en problemas relacionados con salud ocupacional. RISKGATE provee un ambiente en la captura de conocimiento y reciprocidad en un mundo de innovación e intercambio de prácticas actuales a través de la industria en la identificación, evaluación y manejo de riesgo. En la captura del conocimiento operacional por medio de expertos industriales, RISKGATE provee memoria corporativa acumulativa en un momento de alta rotación del personal en la industria del carbón. Este artículo presenta una visión en conjunto de los primeros diecisiete tópicos, estructura de los tópicos y contraste de relaciones internas entre los tópicos. La segunda parte del articulo discute algunos primeros pasos que las compañías están tomando para integrar RISKGATE en estas operaciones; y concluye con algunos ideas en donde RISKGATE puede ir en un futuro

The major Australian Coal Association Research Program (ACARP) project, RISKGATE has now completed three years of knowledge capture and system development. The body of knowledge for risk management of tyres, collisions, fires, isolation, strata underground, ground control open cut, explosions, explosives underground, explosives open cut, manual tasks and slips/trips/falls was launched in December 2012. Recently, the project added knowledge about outbursts, coal bumps and bursts, human-machine interface, tailings dams, occupational hygiene and inrush to the original 11 topics. In 2014, the project plans (pending ACARP funding approval) to focus on issues around Fitness for Work. RISKGATE provides an environment for knowledge capture and knowledge exchange to drive innovation and cross industry sharing of current practice in the identification, assessment and management of risk. By capturing operational knowledge from industry experts, RISKGATE provides a cumulative corporate memory at a time of high personnel turnover in the coal industry. RISKGATE is the largest single ACARP Occupational Health and Safety (OHS) initiative to date. This paper presents an overview of the first seventeen topics, topic structures, and contrasts and inter-relationships between topics. The second part of the paper discusses some early steps that companies are taking to integrate RISKGATE into their operations; and conclude with some thoughts on where RISKGATE can go in the future

Sex pheromones and their impact on pest management.

The idea of using species-specific behavior-modifying chemicals for the management of noxious insects in agriculture, horticulture, forestry, stored products, and for insect vectors of diseases has been a driving ambition through five decades of pheromone research. Hundreds of pheromones and other semiochemicals have been discovered that are used to monitor the presence and abundance of insects and to protect plants and animals against insects. The estimated annual production of lures for monitoring and mass trapping is on the order of tens of millions, covering at least 10 million hectares. Insect populations are controlled by air permeation and attract-and-kill techniques on at least 1 million hectares. Here, we review the most important and widespread practical applications. Pheromones are increasingly efficient at low population densities, they do not adversely affect natural enemies, and they can, therefore, bring about a long-term reduction in insect populations that cannot be accomplished with conventional insecticides. A changing climate with higher growing season temperatures and altered rainfall patterns makes control of native and invasive insects an increasingly urgent challenge. Intensified insecticide use will not provide a solution, but pheromones and other semiochemicals instead can be implemented for sustainable area-wide management and will thus improve food security for a growing population. Given the scale of the challenges we face to mitigate the impacts of climate change, the time is right to intensify goal-oriented interdisciplinary research on semiochemicals, involving chemists, entomologists, and plant protection experts, in order to provide the urgently needed, and cost-effective technical solutions for sustainable insect management worldwide.

Genetic transformation of a Corynebacterial symbiont from the Chagas disease vector Triatoma infestans.

Insect-borne diseases have experienced a troubling resurgence in recent years. Emergence of resistance to pesticides greatly hampers control efforts. Paratransgenesis, or the genetic transformation of bacterial symbionts of disease vectors, is an alternative to traditional approaches. Previously, we developed paratransgenic lines of Rhodnius prolixus, a vector of Chagas disease in Central America. Here, we report identification of a Corynebacterial species as a symbiont of Triatoma infestans, a leading vector of Chagas disease in South America. We have modified this bacterium to produce an immunologically active single chain antibody fragment, termed rDB3. This study establishes the basis for generating paratransgenic T. infestans as a strategy for control of Chagas disease.

Pheromone trap for the eastern tent caterpillar moth.

The discovery that the eastern tent caterpillar Malacosoma americanum (F.) causes mare reproductive loss syndrome (MRLS), and thus has the potential to continue to result in major economic losses to the equine industry of Kentucky, has resulted in an intensive effort to identify practical means to monitor and control this defoliator, including these experiments to optimize a sex pheromone trap for this pest. A pheromone-baited delta trap with a large opening, such as InterceptST Delta, was more effective than other tested traps. Orange delta traps caught more moths than other tested colors. ETC males are caught at all tested heights within the tree canopy. For monitoring flights, setting traps at 1.5 m would allow easy counting of moths. A 9:1 blend of (E,Z)-5,7-dodecadienal (ETC-Ald) and (E,Z)-5,7-dodecadienol (ETC-OH) was most effective in capturing males. Increasing loading doses of a 3:1 blend (Ald:OH) resulted in the capture of increasing numbers of moths, but a 9:1 blend was more effective than 3:1 blend even at a nine-fold lower loading rate. Pheromone-impregnated white septa caught more moths than gray septa at the same loading dose. The advantages and limitations of using pheromone traps for monitoring M. americanum are discussed.