ABSTRACT
An osteosarcoma involving the pelvis was diagnosed in a 9-year-old neutered Labrador bitch. The clinical signs manifested by the patient before surgical removal of the tumor included urinary difficulty, dyschezia, and inconstant non-weight-bearing on the hindlimbs. These signs were linked to the localization of the tumor, which was identified as a firm and painful mass of the size of an orange in the caudal abdomen. The favorable short term clinical results after surgery and carboplatin chemotherapy showed that the association of these approaches can be employed to manage discomfort inflicted by tumor and, therefore improve the quality of life of patient of bone cancer.
Diagnosticou-se um osteossarcoma pélvico em uma cadela da raça Labrador de nove anos. Os sinais clínicos manifestados pela paciente antes da remoção do tumor incluiam dificuldade urinária, disquezia e dificuldade de sustentação do trem posterior. Estes sinais estavam associados à localização do tumor, identificado como uma massa firme e dolorosa do tamanho de uma laranja à região caudal do abdômen. Os resultados clínicos favoráveis observados em curto prazo depois da instauração de tratamento cirúrgico e quimioterápico com carboplatina mostram que a associação dessas condutas pode ser empregada para diminuir o desconforto imposto pelo tumor e, portanto melhorar a qualidade de vida em pacientes com câncer ósseo.
Subject(s)
Animals , Female , Dogs , Drug Therapy , Osteosarcoma , Pelvic NeoplasmsABSTRACT
An inhibitor of interferon's (IFN) antiviral action was evaluated for its ability to block interferon's anticellular action. Crude and partially purified mouse immune interferon (MuIFN-gamma) preparations with high and low levels of an inhibitor of IFN's antiviral action were prepared. These preparations were examined for their relative antiviral and direct anticellular activities. The inhibitor present in the IFN-gamma preparations was found to be an equally potent inhibitor of both the antiviral and the direct anticellular activities of IFN-gamma. Further, while the inhibitor of IFN-gamma was inherently present in most IFN-gamma preparations, it was not an inherent feature of all IFN-gamma molecules. Inhibitor-free IFN-gamma could be separated from inhibitor-containing IFN-gamma by column chromatography. The results suggest that the inhibitor generally antagonizes interferon action and should be taken into account when evaluating the biological properties of IFN-gamma preparations.
