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Eksp Klin Farmakol ; 79(3): 31-6, 2016.
Article in Russian | MEDLINE | ID: mdl-27455576

ABSTRACT

Experiments on the model of immobilization stress in albino mice showed that a combination of mexidol, thymogen, and hyperbaric oxygenation reduced adverse effects of diazepam on behavioral response of animals in the black-and-white chamber and elevated cross maze tests and led to optimization of the blood gas composition as manifested by increased oxygen tension, normalization of the partial pressure of carbon dioxide, and restoration of the acid-base balance and blood bicarbonate level. The proposed combined treatment can be recommended for the treatment of patients with stress-induced pathology.


Subject(s)
Anti-Anxiety Agents/pharmacology , Antioxidants/pharmacology , Dipeptides/pharmacology , Immunologic Factors/pharmacology , Picolines/pharmacology , Stress, Psychological/therapy , Acid-Base Equilibrium , Animals , Blood Gas Analysis , Carbon Dioxide/blood , Diazepam/adverse effects , Diazepam/antagonists & inhibitors , Female , Hyperbaric Oxygenation , Immobilization , Male , Mice , Oxygen/blood , Partial Pressure , Stress, Psychological/blood , Stress, Psychological/etiology , Stress, Psychological/physiopathology
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