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1.
Bone Joint J ; 100-B(9): 1201-1207, 2018 09.
Article in English | MEDLINE | ID: mdl-30168770

ABSTRACT

Aims: The purpose of this retrospective study was to investigate the clinical relevance of increased facet joint distraction as a result of anterior cervical decompression and fusion (ACDF) for trauma. Patients and Methods: A total of 155 patients (130 men, 25 women. Mean age 42.7 years; 16 to 87) who had undergone ACDF between 1 January 2001 and 1 January 2016 were included in the study. Outcome measures included the Neck Disability Index (NDI) and visual analogue scale (VAS) for pain. Lateral cervical spine radiographs taken in the immediate postoperative period were reviewed to compare the interfacet distance of the operated segment with those of the facet joints above and below. Results: There was a statistically significant relationship between greater facet distraction and increased NDI and VAS pain scores. This was further confirmed by Spearman correlation, which showed evidence of a moderate correlation between both NDI score and facet joint distraction (Spearman correlation coefficient 0.34; p < 0.001) and VAS score and facet distraction (Spearman correlation coefficient 0.52; p < 0.001). Furthermore, there was a discernible transition point between outcome scores. Significantly worse outcomes, in terms of both NDI scores (17.8 vs 8.2; p < 0.001) and VAS scores (4.5 vs 1.3; p < 0.001), were seen with facet distraction of 3 mm or more. Patients who went on to have a posterior fusion also had increased NDI and VAS scores, independent of facet distraction. Conclusion: After undergoing ACDF for the treatment of cervical spine injury, patients with facet joint distraction of 3 mm or more have worse NDI and VAS pain scores. Cite this article: Bone Joint J 2018;100-B:1201-7.


Subject(s)
Cervical Vertebrae/surgery , Diskectomy/methods , Osteogenesis, Distraction/methods , Spinal Fusion/methods , Spinal Injuries/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Decompression, Surgical/methods , Disability Evaluation , Female , Humans , Male , Middle Aged , Pain Measurement , Retrospective Studies , Treatment Outcome , Young Adult
2.
Bone Joint J ; 100-B(4): 468-474, 2018 04 01.
Article in English | MEDLINE | ID: mdl-29629578

ABSTRACT

Aims: The aim of this retrospective study was to compare the functional and radiological outcomes of bridge plating, screw fixation, and a combination of both methods for the treatment of Lisfranc fracture dislocations. Patients and Methods: A total of 108 patients were treated for a Lisfranc fracture dislocation over a period of nine years. Of these, 38 underwent transarticular screw fixation, 45 dorsal bridge plating, and 25 a combination technique. Injuries were assessed preoperatively according to the Myerson classification system. The outcome measures included the American Orthopaedic Foot and Ankle Society (AOFAS) score, the validated Manchester Oxford Foot Questionnaire (MOXFQ) functional tool, and the radiological Wilppula classification of anatomical reduction. Results: Significantly better functional outcomes were seen in the bridge plate group. These patients had a mean AOFAS score of 82.5 points, compared with 71.0 for the screw group and 63.3 for the combination group (p < 0.001). Similarly, the mean Manchester Oxford Foot Questionnaire score was 25.6 points in the bridge plate group, 38.1 in the screw group, and 45.5 in the combination group (p < 0.001). Functional outcome was dependent on the quality of reduction (p < 0.001). A trend was noted which indicated that plate fixation is associated with a better anatomical reduction (p = 0.06). Myerson types A and C2 significantly predicted a poorer functional outcome, suggesting that total incongruity in either a homolateral or divergent pattern leads to worse outcomes. The greater the number of columns fixed the worse the outcome (p < 0.001). Conclusion: Patients treated with dorsal bridge plating have better functional and radiological outcomes than those treated with transarticular screws or a combination technique. Cite this article: Bone Joint J 2018;100-B:468-74.


Subject(s)
Bone Plates , Bone Screws , Fracture Dislocation/surgery , Fracture Fixation, Internal/methods , Intra-Articular Fractures/surgery , Metatarsal Bones/injuries , Adult , Aged , Female , Follow-Up Studies , Fracture Dislocation/diagnostic imaging , Fracture Fixation, Internal/instrumentation , Humans , Intra-Articular Fractures/diagnostic imaging , Male , Metatarsal Bones/diagnostic imaging , Middle Aged , Radiography , Recovery of Function , Retrospective Studies , Treatment Outcome
3.
Fiziol Zh SSSR Im I M Sechenova ; 62(9): 1349-54, 1976 Sep.
Article in Russian | MEDLINE | ID: mdl-1087612

ABSTRACT

The frog's electrical activity of the carotid body chemoreceptors reacting to thrombin was studied. The chemoreceptor response was estimated by means of afferent impulsation in the n. glossopharingeus. The afferent impulsation frequency increases to a certain extent in proportion to the irritant concentration; too high a thrombin concentration is able to suppress the chemoreceptor activity. The direct dependence between the receptor response and the effector reaction diminishing the blood coagulation, was established. The receptors adapt slowly, their discharge is of an irregular character.


Subject(s)
Carotid Body/drug effects , Thrombin/pharmacology , Animals , Blood Coagulation , Dose-Response Relationship, Drug , Electrophysiology , Glossopharyngeal Nerve/physiology , Rana temporaria , Thromboplastin/pharmacology
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